Ethylene glycol bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA) inhibits the growth of Escherichia coli at alkaline pH

被引：2
|
作者：
Arakawa, Y [1 ]
Saito, T [1 ]
Saito, H [1 ]
Kakegawa, T [1 ]
Kobayashi, H [1 ]
机构：
[1] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
来源：
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY | 2000年 / 46卷 / 03期
关键词：
alkaline pH; calcium ions; EGTA; Escherichia coli; growth;
D O I：
10.2323/jgam.46.127
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The growth of Escherichia coli was inhibited by ethylene glycol bis(beta-aminoethyl ether)N,N,N',N'-tetraacetic acid (EGTA) in a medium of initial pH 8.8. The growth inhibition was reversed by the addition of CaCl2. E. coli could grow in the presence of EGTA at pH values below 8. The concentration of free calcium ions increases with a decrease in medium pH because of a decrease in the calcium binding capacity of EGTA. So, although the results suggest that calcium ions are essential for the growth of E. coli, the minimum concentration required is very low.
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页码：127 / 131
页数：5
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