SEPSIS CLINICAL CRITERIA IN EMERGENCY DEPARTMENT PATIENTS ADMITTED TO AN INTENSIVE CARE UNIT: AN EXTERNAL VALIDATION STUDY OF QUICK SEQUENTIAL ORGAN FAILURE ASSESSMENT

Background: Quick Sequential Organ Failure Assessment (qSOFA) is a prognostic score for patients with sepsis. Objective: Our aim was to compare the area under the receiver operating curve (AUROC), sensitivity, specificity, and likelihood ratios of qSOFAvs. systemic inflammation response syndrome (SIRS) in predicting inhospital mortality among emergency department (ED) patients with suspected infection admitted to intensive care units (ICUs). Methods: We conducted a retrospective cohort chart review study of ED patients admitted to an ICU with suspected infection from August 1, 2012 to February 28, 2015. We included all patients with body fluid cultures sampled either during their ED stay without antibiotic administration or within 24 h of antibiotics administered in the ED. Trained chart abstractors blinded to the study hypothesis double-entered data from each patient's electronic medical record including demographic characteristics, vital signs, laboratory study results, physical examination findings, and in-hospital mortality. We then calculated the AUROC, sensitivity, specificity, and likelihood ratios for qSOFA and SIRS for predicting in-hospital mortality. Results: Of 214 patients admitted to an ICU with presumed sepsis, 39 (18.2%) died during hospitalization. The AUROC value was 0.65 (95% confidence interval [CI] 0.56-0.74) for SIRS vs. 0.66 (95% CI 0.57-0.76) for qSOFA; 2+ qSOFA criteria predicted in-hospital mortality with 89.7% sensitivity, 27.4% specificity, 1.2 positive likelihood ratio, and 0.4 negative likelihood ratio. Conclusions: Among ED patients admitted to an ICU, the SIRS and qSOFA criteria had comparable prognostic value for predicting inhospital mortality. These prognostic values are similar to those reported by the Sepsis-3 guidelines for ICU encounters. Published by Elsevier Inc.