Understanding and Manipulating Viral Immunity: Antibody Immunodominance Enters Center Stage

被引：65

作者：

Angeletti, Davide ^{[1
]}

Yewdell, Jonathan W. ^{[1
]}

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 07期

关键词：

T-CELL IMMUNODOMINANCE; INFLUENZA-A VIRUS; CLASS-I ALLELES; GERMINAL CENTER; PRECURSOR FREQUENCY; B-CELLS; AFFINITY MATURATION; ANTIGENIC STRUCTURE; HEMAGGLUTININ-STEM; CLONAL SELECTION;

D O I：

10.1016/j.it.2018.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adaptive immune responses against antigenically variable viruses and cellular pathogens are efficient in many cases, but largely limited to the infecting or immunizing strain. A major factor that limits immunity is immunodominance (ID), the hierarchical focusing of adaptive immune responses on a subset of antigenic determinants. While CD8(+) T cell ID has been extensively studied, studies of basic mechanisms of B cell ID are limited, despite the importance of antibodies (Abs) for durable protection against pathogens. Here, we review recent progress in understanding the basic rules and mechanisms of B cell ID, compare B and CD8(+) T cell ID, and outline challenges to overcoming ID to develop Ab-based 'universal' vaccines for influenza A and other highly variable viruses.

引用

页码：549 / 561

页数：13

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