Vanilloid and Melastatin Transient Receptor Potential Channels in Vascular Smooth Muscle

被引：50

作者：

Earley, Scott ^{[1
]}

机构：

[1] Colorado State Univ, Vasc Physiol Res Grp, Dept Biomed Sci, Ft Collins, CO 80523 USA

来源：

MICROCIRCULATION | 2010年 / 17卷 / 04期

关键词：

cation channels; smooth muscle; TRP channels; NONSELECTIVE CATION CHANNEL; HEAT-EVOKED ACTIVATION; 2-AMINOETHOXYDIPHENYL BORATE; ION-CHANNEL; TRPV4; CHANNELS; MYOGENIC TONE; FUNCTIONAL-CHARACTERIZATION; EPOXYEICOSATRIENOIC ACIDS; CA2+-PERMEABLE CHANNEL; RESISTANCE ARTERIES;

D O I：

10.1111/j.1549-8719.2010.00026.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>The mammalian transient receptor potential (TRP) superfamily consists of six subfamilies that are defined by structural homology: TRPC (conventional or canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPP (polycystin), and TRPML (mucoliptin). This review focuses on channels belonging to the vanilloid (V) and melastatin (M) TRP subfamilies. The TRPV subfamily consists of six members (TRPV1-6) and the TRPM subfamily has eight (TRPM1-8). The basic biophysical properties of these channels are briefly described. All of these channels except TRPV5, TRPV6, and TRPM1 are reportedly present in arterial smooth muscle from various segments of the vasculature. Studies demonstrating involvement of TRPV1, TRPV2, TRPV4, TRPM4, TRPM7, and TRPM8 in regulation of arterial smooth muscle function are reviewed. The functions of TRPV3, TRPM2, TRPM3, and TRPM6 channels in arterial myocytes have not been reported.

引用

页码：237 / 249

页数：13

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