The emerging role of RNA N6-methyladenosine methylation in breast cancer

被引：28

作者：

Zheng, Fangchao ^{[1
]}

Du, Feng ^{[2
]}

Zhao, Jiuda ^{[3
,4
]}

Wang, Xue ^{[5
]}

Si, Yiran ^{[1
]}

Jin, Peng ^{[6
]}

Qian, Haili ^{[7
]}

Xu, Binghe ^{[1
]}

Yuan, Peng ^{[1
,5
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Med Oncol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, 17 Panjiayuan Nanli, Beijing 100021, Peoples R China

[2] Peking Univ Canc Hosp & Inst, VIPII Gastrointestinal Canc Div, Dept Med, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100021, Peoples R China

[3] Qinghai Univ, Affiliated Hosp, Breast Dis Diag & Treatment Ctr, Xining 810000, Peoples R China

[4] Qinghai Univ, Affiliated Canc Hosp, Xining 810000, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Dept VIP Med Serv, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China

[6] Chinese Acad Med Sci & Peking Union Med Coll, Dept Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China

[7] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Mol Oncol, Canc Hosp Inst, Beijing 100021, Peoples R China

来源：

BIOMARKER RESEARCH | 2021年 / 9卷 / 01期

基金：

国家重点研发计划;

关键词：

RNA methylation; Breast cancer; Clinicopathological features; Prognosis; Drug target; ESTROGEN-RECEPTOR-ALPHA; MESSENGER-RNAS; PROGNOSTIC VALUE; STRUCTURAL BASIS; POOR-PROGNOSIS; CELL-ADHESION; METASTASIS; TUMOR; IMP3; PROMOTES;

D O I：

10.1186/s40364-021-00295-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.

引用

页数：15

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