C1 Domains: Structure and Ligand-Binding Properties

被引：72

作者：

Das, Joydip ^{[1
]}

Rahman, Ghazi M. ^{[1
]}

机构：

[1] Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA

来源：

CHEMICAL REVIEWS | 2014年 / 114卷 / 24期

关键词：

PROTEIN-KINASE-C; PHORBOL ESTER-BINDING; CONFORMATIONALLY CONSTRAINED ANALOGS; CYSTEINE-RICH REGION; GREEN FLUORESCENT PROTEIN; X-RAY CRYSTALLOGRAPHY; PROSTATE-CANCER CELLS; PKC-ALPHA ACTIVITY; DAPHNE MEZEREUM L; TUMOR PROMOTERS;

D O I：

10.1021/cr300481j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The role of the C1 domain in membrane translocation and activation of PKCs has been well-studied. PKCs belong to the superfamily of serine threonine kinases that play a central role in intracellular signal transduction and regulate divergent cellular functions, such as cell growth, cell differentiation, metabolism, and apoptosis by phosphorylating target proteins. Recent review articles on C1 domains primarily highlight its role in the activation of the related signaling pathways and its importance as a target for natural and synthetic ligands. The present article provides a comprehensive structural analysis of various C1 domains, and their binding affinity for various natural and synthetic ligands, and it discusses structural basis of ligand-binding, and the future perspectives of research on C1domains.

引用

页码：12108 / 12131

页数：24

共 250 条

[1]

ACS G, 1995, J NEUROCHEM, V65, P301

[2]

ADOLF W, 1983, J SCI SOC THAILAND, V9, P81

[3] Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates [J].

af Gennas, Gustav Boije ;

Talman, Virpi ;

Yli-Kauhaluoma, Jari ;

Tuominen, Raimo K. ;

Ekokoski, Elina .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2011, 11 (11) :1370-1392

[4] Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C [J].

af Gennas, Gustav Boije ;

Talman, Virpi ;

Aitio, Olli ;

Ekokoski, Elina ;

Finel, Moshe ;

Tuominen, Raimo K. ;

Yli-Kauhaluoma, Jari .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (13) :3969-3981

[5] Protein kinase C-ε (PKC-ε):: Its unique structure and function [J].

Akita, Y .

JOURNAL OF BIOCHEMISTRY, 2002, 132 (06) :847-852

[6] PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease [J].

Alkon, Daniel L. ;

Sun, Miao-Kun ;

Nelson, Thomas J. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2007, 28 (02) :51-60

[7] Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains [J].

Ananthanarayanan, B ;

Stahelin, RV ;

Digman, MA ;

Cho, WH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (47) :46886-46894

[8] Individual C1 domains of PKD3 in phorbol ester-induced plasma membrane translocation of PKD3 in intact cells [J].

Anderson, G ;

Chen, J ;

Wang, QJ .

CELLULAR SIGNALLING, 2005, 17 (11) :1397-1411

[9] ADRIAMYCIN, 14-HYDROXYDAUNOMYCIN, A NEW ANTITUMOR ANTIBIOTIC FROM S-PEUCETIUS VAR CAESIUS [J].

ARCAMONE, F ;

CASSINEL.G ;

FANTINI, G ;

GREIN, A ;

OREZZI, P ;

POL, C ;

SPALLA, C .

BIOTECHNOLOGY AND BIOENGINEERING, 1969, 11 (06) :1101-&

[10] ACTIVATION OF PROTEIN KINASE-C BY TUMOR PROMOTING PHORBOL ESTERS, TELEOCIDIN AND APLYSIATOXIN IN THE ABSENCE OF ADDED CALCIUM [J].

ARCOLEO, JP ;

WEINSTEIN, IB .

CARCINOGENESIS, 1985, 6 (02) :213-217

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