Glycobiology of α-dystroglycan and muscular dystrophy

被引：109

作者：

Endo, Tamao ^{[1
,2
]}

机构：

[1] Tokyo Metropolitan Geriatr Hosp, Tokyo 1730015, Japan

[2] Inst Gerontol, Tokyo 1730015, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2015年 / 157卷 / 01期

关键词：

dystroglycan; glycan biosynthesis; glycosyltransferase; muscular dystrophy; O-mannosyl glycan; WALKER-WARBURG-SYNDROME; PROTEIN O-MANNOSYLATION; GDP-MANNOSE PYROPHOSPHORYLASE; RABBIT SKELETAL-MUSCLE; LAMININ-BINDING; DEFECTIVE GLYCOSYLATION; ABNORMAL GLYCOSYLATION; GENE POMT1; MUTATIONS; GLYCANS;

D O I：

10.1093/jb/mvu066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most proteins are modified by glycans, which can modulate the biological properties and functions of glycoproteins. The major glycans can be classified into N-glycans and O-glycans according to their glycan-peptide linkage. This review will provide an overview of the O-mannosyl glycans, one subtype of O-glycans. Originally, O-mannosyl glycan was only known to be present on a limited number of glycoproteins, especially alpha-dystroglycan (alpha-DG). However, once a clear relationship was established between O-mannosyl glycan and the pathological mechanisms of some congenital muscular dystrophies in humans, research on the biochemistry and pathology of O-mannosyl glycans has been expanding. Because alpha-DG glycosylation is defective in congenital muscular dystrophies, which also feature abnormal neuronal migration, these disorders are collectively called alpha-dystroglycanopathies. In this article, I will describe the structure, biosynthesis and pathology of O-mannosyl glycans.

引用

页码：1 / 12

页数：12

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