Application of the genetic risk model for the analysis of predisposition to nonlacunar ischemic stroke

被引：1

作者：

Korchagin, Vitaly ^{[1
]}

Mironov, Konstantin ^{[1
]}

Platonov, Alexander ^{[1
]}

Dribnokhodova, Olga ^{[1
]}

Akselrod, Elina ^{[1
]}

Dunaeva, Elena ^{[1
]}

Stolyar, Marina ^{[2
,3
]}

Gorbenko, Aleksey ^{[2
,3
]}

Gritsan, Galina ^{[4
]}

Olkhovskiy, Igor ^{[2
,3
]}

Rakova, Natalia ^{[5
]}

Roytman, Alexander ^{[5
]}

Sotnikov, Alexander ^{[5
]}

Raskurazhev, Anton ^{[6
]}

Maksimova, Marina ^{[6
]}

Tanashyan, Marine ^{[6
]}

Illarioshkin, Sergey ^{[6
]}

Shipulin, German ^{[1
]}

机构：

[1] Cent Res Inst Epidemiol, Moscow, Russia

[2] Hematol Res Ctr, Dept Hlth, Fed State Budgetary Inst, Krasnoyarsk Branch, Krasnoyarsk, Russia

[3] Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk, Russia

[4] Krasnoyarsk State Med Univ, Krasnoyarsk, Russia

[5] Moscow City Clin Hosp, Moscow, Russia

[6] Res Ctr Neurol, Moscow, Russia

来源：

PERSONALIZED MEDICINE | 2019年 / 16卷 / 05期

关键词：

genetic susceptibility; ischemic stroke; single-nucleotide polymorphism; PREDICTION; DISEASE; LOCI;

D O I：

10.2217/pme-2018-0104

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: The purpose of our study was to analyze the predictive ability of the multiplicative model of genetic risk of nonlacunar ischemic stroke (IS) for independent samples from Russia. Patients & methods: A total of 181 patients and 360 healthy controls were included in this study. The discriminative accuracy of model was evaluated by the area under the receiver operating characteristic curve (AUC). Results: Classification model based on 15 single-nucleotide polymorphisms (SNPs), which are associated with a cardioembolic subtype of IS, had an AUC of 0.62 in patients with corresponding subtypes and an AUC of 0.58 for all patients. Conclusion: Risk calculation approach based on IS-associated SNPs had satisfactory performance in predicting the predisposition to the disease.

引用

页码：369 / 378

页数：10

共 50 条

[1] Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score
Hachiya, Tsuyoshi
Kamatani, Yoichiro
Takahashi, Atsushi
Hata, Jun
Furukawa, Ryohei
Shiwa, Yuh
Yamaji, Taiki
Hara, Megumi
Tanno, Kozo
Ohmomo, Hideki
Ono, Kanako
Takashima, Naoyuki
Matsuda, Koichi
Wakai, Kenji
Sawada, Norie
Iwasaki, Motoki
Yamagishi, Kazumasa
Ago, Tetsuro
Ninomiya, Toshiharu
Fukushima, Akimune
Hozawa, Atsushi
Minegishi, Naoko
Satoh, Mamoru
Endo, Ryujin
Sasaki, Makoto
Sakata, Kiyomi
Kobayashi, Seiichiro
Ogasawara, Kuniaki
Nakamura, Motoyuki
Hitomi, Jiro
Kita, Yoshikuni
Tanaka, Keitaro
Iso, Hiroyasu
Kitazono, Takanari
Kubo, Michiaki
Tanaka, Hideo
Tsugane, Shoichiro
Kiyohara, Yutaka
Yamamoto, Masayuki
Sobue, Kenji
Shimizu, Atsushi
STROKE, 2017, 48 (02) : 253 - 258
[2] Association between genetic predisposition of AF and the risk of ischemic stroke and thromboembolism
Lai, Y.
Li, S.
Li, M.
Jiang, C.
Sang, C.
Du, X.
Dong, J.
Ma, C.
EUROPEAN HEART JOURNAL, 2024, 45
[3] Association between genetic predisposition of AF and the risk of ischemic stroke and thromboembolism
Lai, Y.
Li, S.
Li, M.
Jiang, C.
Sang, C.
Du, X.
Dong, J.
Ma, C.
EUROPEAN HEART JOURNAL, 2024, 45
[4] HEREDITARY PREDISPOSITION AS A RISK FACTOR IN ISCHEMIC STROKE DEVELOPMENT
DAVIDENKOVA, EF
KOLOSOVA, NN
LIBERMAN, IS
GRIGORYEVA, VV
SHAFRAN, MG
ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 1982, 82 (08): : 1124 - 1131
[5] Pooled Genetic Analysis Reveals an Association of SNPs of Only a Few Genes with Risk Predisposition to Ischemic Stroke in a Chinese Population
Zhang, Zhenchang
Su, Gang
Guo, Jia
Li, Jiong
Wu, Hua
Wang, Manxia
Xie, Xiaodong
IUBMB LIFE, 2015, 67 (03) : 170 - 174
[6] The Role of Genetic Factors in the Development of Individual Predisposition to Ischemic Stroke
Korchagin V.I.
Mironov K.O.
Dribnokhodova O.P.
Maksimova M.Y.
Illarioshkin S.N.
Tanashyan M.M.
Platonov A.E.
Shipulin G.A.
Raskurazhev A.A.
Piradov M.A.
Human Physiology, 2017, 43 (8) : 886 - 897
[7] Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex
Traylor, Matthew
Rutten-Jacobs, Loes C. A.
Holliday, Elizabeth G.
Malik, Rainer
Sudlow, Cathie
Rothwell, Peter M.
Maguire, Jane M.
Koblar, Simon A.
Bevan, Steve
Boncoraglio, Giorgio
Dichgans, Martin
Levi, Chris
Lewis, Cathryn M.
Markus, Hugh S.
STROKE, 2015, 46 (11) : 3042 - 3047
[8] Transoesophageal echocardiographic findings in patients with ischemic lacunar and nonlacunar stroke
Cokar, Ozlem
Ozturk, Oya
Aydemir, Tuba
Tiras, Raziye
Ozer, Feriha
Hakyemez, Husniye Aylin
JOURNAL OF CLINICAL NEUROSCIENCE, 2008, 15 (03) : 246 - 252
[9] Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke
Battey, Thomas W. K.
Karki, Mahima
Singhal, Aneesh B.
Wu, Ona
Sadaghiani, Saloomeh
Campbell, Bruce C. V.
Davis, Stephen M.
Donnan, Geoffrey A.
Sheth, Kevin N.
Kimberly, W. Taylor
STROKE, 2014, 45 (12) : 3643 - +
[10] Genetic Predisposition to Diabetes and Risk of Stroke in Native Hawaiians
Brown, Stacy C.
Both, Cameron
Dowsett, Leah
Fox, Keolu
Nakagawa, Kazuma
Gerschenson, Mariana
Falcone, Guido J.
STROKE, 2024, 55

← 1 2 3 4 5 →