Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment

被引：86
作者：
Gallagher, M
Bizon, JL
Hoyt, EC
Helm, KA
Lund, PK
机构：
[1] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA
[2] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC USA
来源：
EXPERIMENTAL GERONTOLOGY | 2003年 / 38卷 / 1-2期
关键词：
rats; spatial memory; hippocampus; NF kappa B; glucocorticoids; synaptic protein;
D O I：
10.1016/S0531-5565(02)00159-6
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Vertical integration is being used to great advantage in neurobiological research on the basis of age-related cognitive decline. Such research bridges analysis between the molecular and cellular levels and the outcome of impaired psychological functions. Current use of animals models within this paradigm has defined mild cognitive impairment in a subpopulation of outbred aged Long-Evans rats by assessment of hippocampal-dependent spatial cognition. Aged rats with cognitive impairment exhibited no loss of neurons in the hippocampus. Current research is focused on the functional alterations in neurons by methods which assess transcriptional mechanisms and signaling pathways. (C) 2002 Elsevier Science Inc. All rights reserved.
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页码：71 / 77
页数：7
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