Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

被引：31

作者：

Zaph, C ^{[1
]}

Scott, PS ^{[1
]}

机构：

[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 03期

关键词：

D O I：

10.1128/IAI.71.3.1587-1589.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

引用

页码：1587 / 1589

页数：3

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