Synthesis and biological evaluation, of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors

被引：22

作者：

Benfatti, Fides ^{[1
]}

Cardillo, Giuliana ^{[1
]}

Gentilucci, Luca ^{[1
]}

Tolomelli, Alessandra ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 07期

关键词：

Acyl-CoA cholesterol O-acyltransferase; beta-lactams; cholesterol absorption inhibition; azides; spiro derivatives;

D O I：

10.1016/j.bmcl.2007.01.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Unprecedented classes of four- and five-membered hydroxyl-spiro-beta-lactams and hydroxyl-azido-beta-lactams were prepared via regioselective ring opening of hydroxyl-epoxides. The potential of these particular beta-lactams as biologically active compounds has been confirmed by the results obtained in ACAT inhibition assays. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1946 / 1950

页数：5

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