THE ROLE OF AUTOPHAGY IN MODULATION OF NEUROINFLAMMATION IN MICROGLIA

被引：153
作者：
Su, P. [1 ,2 ]
Zhang, J. [1 ,2 ]
Wang, D. [1 ,2 ]
Zhao, F. [1 ,2 ]
Cao, Z. [1 ,2 ]
Aschner, M. [3 ]
Luo, W. [1 ,2 ]
机构：
[1] Fourth Mil Med Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, 169 Changlexi Rd, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Minist Educ, Sch Publ Hlth, Key Lab Hazard Assessment & Control Special Opera, 169 Changlexi Rd, Xian 710032, Peoples R China
[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
来源：
NEUROSCIENCE | 2016年 / 319卷
关键词：
microglia; inflammation; autophagy; SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; CELL-DEATH; NEURODEGENERATIVE DISEASES; INTRACEREBRAL HEMORRHAGE; IL-1-BETA PRODUCTION; NLRP3; INFLAMMASOME; KINASE-ACTIVITY;
D O I：
10.1016/j.neuroscience.2016.01.035
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglia have multiple functions in regulating homeostasis in the central nervous system (CNS), and microglial inflammation is thought to play a role in the etiology of the neurodegenerative diseases. When endogenous or exogenous stimuli trigger disorders in microenvironmental homeostasis in CNS, microglia critically determine the fate of other neural cells. Recently, it was reported that autophagy might influence inflammation and activation of microglia. Though the interaction between autophagy and macrophages has been reported and reviewed in length, the role of autophagy in microglia has yet to be reviewed. Herein, we will highlight recent advances on the emerging role of autophagy in microglia, focusing on the regulation of autophagy during microglial inflammation, and the possible mechanism involved. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：155 / 167
页数：13
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