Rituximab treatment in rheumatoid arthritis: how does it work?

被引：19

作者：

Boumans, Maria J. H. ^{[1
]}

Tak, Paul P. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Div Clin Immunol & Rheumatol, NL-1100 DE Amsterdam, Netherlands

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 06期

关键词：

B-CELL DEPLETION; BONE-MARROW; PERIPHERAL-BLOOD; THERAPY; REGENERATION;

D O I：

10.1186/ar2852

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment with the chimerical monoclonal antibody rituximab results in CD20-directed B cell depletion. Although this depletion is almost complete in the peripheral blood of nearly all patients with rheumatoid arthritis, a proportion of patients does not exhibit a clinical response. The paper by Nakou and colleagues suggests that a decrease in CD19+CD27+ memory B cells in both peripheral blood and bone marrow precedes the clinical response to rituximab. This finding adds to the emerging evidence that lack of response to rituximab is associated with persistence of B lineage cells in specific body compartments.

引用

页数：2

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