NEURODEGENERATION An Alzheimer's-disease-protective APOE mutation

被引：14
|
作者：
Zalocusky, Kelly A. [1 ,2 ]
Nelson, Maxine R. [1 ,3 ]
Huang, Yadong [1 ,2 ,3 ]
机构：
[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94115 USA
[3] Univ Calif San Francisco, Biomed Sci Program, San Francisco, CA 94143 USA
来源：
NATURE MEDICINE | 2019年 / 25卷 / 11期
关键词：
APOLIPOPROTEIN-E; RISK;
D O I：
10.1038/s41591-019-0634-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer's disease until her seventies.
引用
收藏
页码：1648 / 1649
页数：2
相关论文
共 50 条
  • [31] The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease
    Leoni, Valerio
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2011, 49 (03) : 375 - 383
  • [32] Alzheimer's disease neurodegeneration markers in Alzheimer's disease neuroimaging initiative
    Andriuta, D.
    Moullart, V.
    Schraen, S.
    Meyer, M. -E.
    Godefroy, O.
    EUROPEAN JOURNAL OF NEUROLOGY, 2015, 22 : 93 - 93
  • [33] ALZHEIMER DISEASE ApoE4 implicated in tau-mediated neurodegeneration
    Wood, Heather
    NATURE REVIEWS NEUROLOGY, 2017, 13 (12) : 706 - 706
  • [34] New insights into innate immunity in Alzheimer's disease: from APOE protective variants to therapies
    Chen, Yun
    Holtzman, David M.
    TRENDS IN IMMUNOLOGY, 2024, 45 (10) : 768 - 782
  • [35] S-Nitrosylation of ApoE in Alzheimer's Disease
    Abrams, Alexander J.
    Farooq, Amjad
    Wang, Gaofeng
    BIOCHEMISTRY, 2011, 50 (17) : 3405 - 3407
  • [36] APOE and metabolic dysfunction in Alzheimer's disease
    Johnson, Lance A.
    METABOLIC AND BIOENERGETIC DRIVERS OF NEURODEGENERATIVE DISEASE: NEURODEGENERATIVE DISEASE RESEARCH AND COMMONALITIES WITH METABOLIC DISEASES, 2020, 154 : 131 - 151
  • [37] The ApoE gene of Alzheimer's disease (AD)
    P. K. Krishnan Namboori
    K. V. Vineeth
    V. Rohith
    Ibnul Hassan
    Lekshmi Sekhar
    Akhila Sekhar
    M. Nidheesh
    Functional & Integrative Genomics, 2011, 11 : 519 - 522
  • [38] APOE, Alzheimer's Disease, and Hispanic Populations
    Blue, Elizabeth E.
    Horimoto, Andrea R. V. R.
    Wijsman, Ellen M.
    Thornton, Timothy A.
    GENETIC EPIDEMIOLOGY, 2018, 42 (07) : 690 - 690
  • [39] The evolution of Alzheimer's disease and ApoE isoforms
    Bons, N
    NEUROBIOLOGY OF AGING, 1999, 20 (04) : 455 - 456
  • [40] APOE and cholesterol homeostasis in Alzheimer's disease
    Leduc, Valerie
    Jasmin-Belanger, Stephanie
    Poirier, Judes
    TRENDS IN MOLECULAR MEDICINE, 2010, 16 (10) : 469 - 477
12345