NEURODEGENERATION An Alzheimer's-disease-protective APOE mutation

被引：14
|
作者：
Zalocusky, Kelly A. [1 ,2 ]
Nelson, Maxine R. [1 ,3 ]
Huang, Yadong [1 ,2 ,3 ]
机构：
[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94115 USA
[3] Univ Calif San Francisco, Biomed Sci Program, San Francisco, CA 94143 USA
来源：
NATURE MEDICINE | 2019年 / 25卷 / 11期
关键词：
APOLIPOPROTEIN-E; RISK;
D O I：
10.1038/s41591-019-0634-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer's disease until her seventies.
引用
收藏
页码：1648 / 1649
页数：2
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