Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory

被引：19
作者：
Bosch, Lander [1 ,2 ]
Bosch, Barbara [3 ,4 ]
De Boeck, Kris [4 ]
Nawrot, Tim [5 ,6 ]
Meyts, Isabelle [4 ]
Vanneste, Dominique [7 ]
Le Bourlegat, Cleonice Alexandre [8 ]
Croda, Julio [2 ,9 ]
Ferreira da Silva Filho, Luiz Vicente Ribeiro [10 ,11 ]
机构：
[1] Univ Cambridge, Dept Geog, Downing Pl, Cambridge CB2 3EN, England
[2] Fundacao Oswaldo Cruz Mato Grosso do Sul, Rua Gabriel Abrao S-N, BR-79081746 Campo Grande, MS, Brazil
[3] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10065 USA
[4] Univ Hosp Leuven, Dept Pediat, Herestr 49, B-3000 Leuven, Belgium
[5] Hasselt Univ, Ctr Environm Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium
[6] KULeuven, Dept Publ Hlth & Primary Care, Occupat & Environm Med, Herestr 49, B-3000 Leuven, Belgium
[7] KULeuven, Div Geog, Celestijnenlaan 200E, B-3001 Leuven, Belgium
[8] Univ Catolica Dom Bosco, Desenvolvimento Seminario, Ave Tamandare 6000, BR-70117900 Campo Grande, MS, Brazil
[9] Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Rodovia Dourados,Itahum Km 12,Cidade Univ, BR-79804970 Dourados, MS, Brazil
[10] Univ Sao Paulo, Inst Crianca, Hosp Clin, Sch Med, Ave Dr Eneas Carvalho de Aguiar 647, BR-05403000 Sao Paulo, SP, Brazil
[11] Hosp Israelita Albert Einstein, Inst Ensino & Pesquisa, Ave Albert Einstein 627, BR-05652000 Sao Paulo, SP, Brazil
来源：
BMC INFECTIOUS DISEASES | 2017年 / 17卷
关键词：
Cystic fibrosis; Tuberculosis; Spatial epidemiology; Brazil; Resistance genetics; NONTUBERCULOUS MYCOBACTERIA; INBORN-ERRORS; LOW-FREQUENCY; CFTR GENE; MUTATION; SUSCEPTIBILITY; DETERMINANTS; POPULATION; IMMUNITY; DISEASE;
D O I：
10.1186/s12879-017-2448-z
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis(Mtb) infection. Methods: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis ( TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2. Smoking data were incomplete and not available for analysis. Results: A significant, negative correlation between CF carriership rate and TB incidence, independent of any of the seven confounders was found. Conclusion: We provide exploratory support for the hypothesis that carrying a single CFTR mutation arms against Mtb infections.
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页数：8
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