Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory

被引：17
作者：
Bosch, Lander [1 ,2 ]
Bosch, Barbara [3 ,4 ]
De Boeck, Kris [4 ]
Nawrot, Tim [5 ,6 ]
Meyts, Isabelle [4 ]
Vanneste, Dominique [7 ]
Le Bourlegat, Cleonice Alexandre [8 ]
Croda, Julio [2 ,9 ]
Ferreira da Silva Filho, Luiz Vicente Ribeiro [10 ,11 ]
机构：
[1] Univ Cambridge, Dept Geog, Downing Pl, Cambridge CB2 3EN, England
[2] Fundacao Oswaldo Cruz Mato Grosso do Sul, Rua Gabriel Abrao S-N, BR-79081746 Campo Grande, MS, Brazil
[3] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10065 USA
[4] Univ Hosp Leuven, Dept Pediat, Herestr 49, B-3000 Leuven, Belgium
[5] Hasselt Univ, Ctr Environm Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium
[6] KULeuven, Dept Publ Hlth & Primary Care, Occupat & Environm Med, Herestr 49, B-3000 Leuven, Belgium
[7] KULeuven, Div Geog, Celestijnenlaan 200E, B-3001 Leuven, Belgium
[8] Univ Catolica Dom Bosco, Desenvolvimento Seminario, Ave Tamandare 6000, BR-70117900 Campo Grande, MS, Brazil
[9] Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Rodovia Dourados,Itahum Km 12,Cidade Univ, BR-79804970 Dourados, MS, Brazil
[10] Univ Sao Paulo, Inst Crianca, Hosp Clin, Sch Med, Ave Dr Eneas Carvalho de Aguiar 647, BR-05403000 Sao Paulo, SP, Brazil
[11] Hosp Israelita Albert Einstein, Inst Ensino & Pesquisa, Ave Albert Einstein 627, BR-05652000 Sao Paulo, SP, Brazil
来源：
BMC INFECTIOUS DISEASES | 2017年 / 17卷
关键词：
Cystic fibrosis; Tuberculosis; Spatial epidemiology; Brazil; Resistance genetics; NONTUBERCULOUS MYCOBACTERIA; INBORN-ERRORS; LOW-FREQUENCY; CFTR GENE; MUTATION; SUSCEPTIBILITY; DETERMINANTS; POPULATION; IMMUNITY; DISEASE;
D O I：
10.1186/s12879-017-2448-z
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis(Mtb) infection. Methods: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis ( TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2. Smoking data were incomplete and not available for analysis. Results: A significant, negative correlation between CF carriership rate and TB incidence, independent of any of the seven confounders was found. Conclusion: We provide exploratory support for the hypothesis that carrying a single CFTR mutation arms against Mtb infections.
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页数：8
相关论文
共 36 条
  • [1] [Anonymous], SIST INF AT BAS
  • [2] Bates M, 2015, COLD SPRING HARB PER, V6
  • [3] Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
    Boisson-Dupuis, Stephanie
    Bustamante, Jacinta
    El-Baghdadi, Jamila
    Camcioglu, Yildiz
    Parvaneh, Nima
    El Azbaoui, Safaa
    Agader, Aomar
    Hassani, Amal
    El Hafidi, Naima
    Mrani, Nidal Alaoui
    Jouhadi, Zineb
    Ailal, Fatima
    Najib, Jilali
    Reisli, Ismail
    Zamani, Adil
    Yosunkaya, Sebnem
    Gulle-Girit, Saniye
    Yildiran, Alisan
    Cipe, Funda Erol
    Torun, Selda Hancerli
    Metin, Ayse
    Atikan, Basak Yildiz
    Hatipoglu, Nevin
    Aydogmus, Cigdem
    Kilic, Sara Sebnem
    Dogu, Figen
    Karaca, Neslihan
    Aksu, Guzide
    Kutukculer, Necil
    Keser-Emiroglu, Melike
    Somer, Ayper
    Tanir, Gonul
    Aytekin, Caner
    Adimi, Parisa
    Mahdaviani, Seyed Alireza
    Mamishi, Setareh
    Bousfiha, Aziz
    Sanal, Ozden
    Mansouri, Davood
    Casanova, Jean-Laurent
    Abel, Laurent
    [J]. IMMUNOLOGICAL REVIEWS, 2015, 264 (01) : 103 - 120
  • [4] Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity
    Bustamante, Jacinta
    Boisson-Dupuis, Stephanie
    Abel, Laurent
    Casanova, Jean-Laurent
    [J]. SEMINARS IN IMMUNOLOGY, 2014, 26 (06) : 454 - 470
  • [5] Cabello GMK, 1999, HUM BIOL, V71, P189
  • [6] Severe infectious diseases of childhood as monogenic inborn errors of immunity
    Casanova, Jean-Laurent
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (51) : E7128 - E7137
  • [7] Benchmarks for Cystic Fibrosis carrier screening: A European consensus document
    Castellani, Carlo
    Macek, Milan, Jr.
    Cassiman, Jean-Jacques
    Duff, Alistair
    Massie, John
    ten Kate, Leo P.
    Barton, David
    Cutting, Garry
    Dallapiccola, Bruno
    Dequeker, Elisabeth
    Girodon, Emmanuelle
    Grody, Wayne
    Highsmith, Edward W.
    Kaariainen, Helenal
    Kruip, Stephan
    Morris, Michael
    Pignatti, Pier Franco
    Pypops, Ulrike
    Schwarz, Martin
    Soller, Maria
    Stuhrman, Manfred
    Cuppens, Harry
    [J]. JOURNAL OF CYSTIC FIBROSIS, 2010, 9 (03) : 165 - 178
  • [8] Revisiting Human IL-12Rβ1 Deficiency A Survey of 141 Patients From 30 Countries
    de Beaucoudrey, Ludovic
    Samarina, Arina
    Bustamante, Jacinta
    Cobat, Aurelie
    Boisson-Dupuis, Stephanie
    Feinberg, Jacqueline
    Al-Muhsen, Saleh
    Janniere, Lucile
    Rose, Yoann
    de Suremain, Maylis
    Kong, Xiao-Fei
    Filipe-Santos, Orchidee
    Chapgier, Ariane
    Picard, Capucine
    Fischer, Alain
    Dogu, Figen
    Ikinciogullari, Aydan
    Tanir, Gonul
    Al-Hajjar, Sami
    Al-Jumaah, Suliman
    Frayha, Husn H.
    Alsum, Zobaida
    Al-Ajaji, Sulaiman
    Alangari, Abdullah
    Al-Ghonaium, Abdulaziz
    Adimi, Parisa
    Mansouri, Davood
    Ben-Mustapha, Imen
    Yancoski, Judith
    Garty, Ben-Zion
    Rodriguez-Gallego, Carlos
    Caragol, Isabel
    Kutukculer, Necil
    Kumararatne, Dinakantha S.
    Patel, Smita
    Doffinger, Rainer
    Exley, Andrew
    Jeppsson, Olle
    Reichenbach, Janine
    Nadal, David
    Boyko, Yaryna
    Pietrucha, Barbara
    Anderson, Suzanne
    Levin, Michael
    Schandene, Liliane
    Schepers, Kinda
    Efira, Andre
    Mascart, Francoise
    Matsuoka, Masao
    Sakai, Tatsunori
    [J]. MEDICINE, 2010, 89 (06) : 381 - 402
  • [9] The relative frequency of CFTR mutation classes in European patients with cystic fibrosis
    De Boeck, K.
    Zolin, A.
    Cuppens, H.
    Olesen, H. V.
    Viviani, L.
    [J]. JOURNAL OF CYSTIC FIBROSIS, 2014, 13 (04) : 403 - 409
  • [10] Highlighting the impact of cascade carrier testing in cystic fibrosis families
    Dugueperoux, Ingrid
    L'Hostis, Carine
    Audrezet, Marie-Pierre
    Rault, Gilles
    Frachon, Irene
    Bernard, Remy
    Parent, Philippe
    Blayau, Martine
    Schmitt, Sebastien
    Genin, Emmanuelle
    Ferec, Claude
    Scotet, Virginie
    [J]. JOURNAL OF CYSTIC FIBROSIS, 2016, 15 (04) : 452 - 459
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