Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

被引：1

作者：

Degtyar', VG ^{[1
]}

Kushlinskii, NE ^{[1
]}

机构：

[1] Russian Acad Med Sci, NN Blokhin Russian Oncol Res Ctr, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2000年 / 129卷 / 05期

关键词：

rats; pituitary gland; androgens; metabolism; role of androgen metabolites;

D O I：

10.1007/BF02439786

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of androgen metabolism and individual androgen metabolites in rat pituitary gland and hypothalamus is discussed on the basis of published data and results of our experiments. It is proposed that metabolism of androgens in these structures is aimed at the formation of not only true sex steroids estradiol-17 beta and 5 alpha-dihydrotestosterone, but also of androgens contributing to the regulation of cell processes, i.e. represents modification (transformation) of androgen signal (testosterone) in target pituitary and hypothalamic cells.

引用

页码：407 / 412

页数：6

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