Chemoprevention of Colorectal Cancer

被引：162

作者：

Katona, Bryson W. ^{[1
]}

Weiss, Jennifer M. ^{[2
]}

机构：

[1] Univ Penn, Dept Med, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA

[2] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Gastroenterol & Hepatol, Madison, WI USA

来源：

GASTROENTEROLOGY | 2020年 / 158卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Colorectal Cancer; Adenoma; Chemoprevention; FAMILIAL ADENOMATOUS POLYPOSIS; LOW-DOSE ASPIRIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ABERRANT CRYPT FOCI; LONG-TERM USE; FOLIC-ACID SUPPLEMENTATION; DAILY SOLUBLE ASPIRIN; VITAMIN-D; COLON-CANCER; PRIMARY PREVENTION;

D O I：

10.1053/j.gastro.2019.06.047

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from CRC, chemoprevention strategies have the potential to further reduce CRC incidence and mortality. Chemoprevention agents might be used for average-risk as well as high-risk groups, and to prevent CRC recurrence after therapy. CRC chemoprevention agents that have been studied include aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals. We review the prospect of chemoprevention of CRC, results from preclinical and human studies, challenges, and future directions.

引用

页码：368 / 388

页数：21

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