Desmosomal Cadherins in Health and Disease

被引:54
作者
Hegazy, Marihan [1 ]
Perl, Abbey L. [1 ]
Svoboda, Sophia A. [1 ]
Green, Kathleen J. [1 ,2 ,3 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
基金
美国国家卫生研究院;
关键词
desmosomes; desmogleins; skin diseases; cardiomyopathy; cell junctions; cancer; INTESTINAL EPITHELIAL BARRIER; N-GLYCOSYLATION AFFECTS; PROTEIN-KINASE-C; DESMOGLEIN; MULTIPLE ALLERGIES; SEVERE DERMATITIS; ARRHYTHMOGENIC CARDIOMYOPATHY; EPIDERMAL DIFFERENTIATION; PEMPHIGUS-VULGARIS; ADHERENS JUNCTIONS;
D O I
10.1146/annurev-pathol-042320-092912
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, which are grouped into desmogleins and desmocollins, are related to the classical cadherins, but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The resulting junctions are critical for resisting mechanical stress in tissues such as the skin and heart. Desmosomal cadherins also act as signaling hubs that promote differentiation and facilitate morphogenesis, creating more complex and effective tissue barriers in vertebrate tissues. Interference with desmosomal cadherin adhesive and supra-adhesive functions leads to a variety of autoimmune, hereditary, toxin-mediated, and malignant diseases. We review our current understanding of how desmosomal cadherins contribute to human health and disease, highlight gaps in our knowledge about their regulation and function, and introduce promising new directions toward combatting desmosome-related diseases.
引用
收藏
页码:47 / 72
页数:26
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