IN VITRO STUDIES OF THE USE OF SOME MEDICINAL HERBALS LEAVES AGAINST ANTIDEPRESSANT, ANALGESIC ACTIVITY, AND ANTI-INFLAMMATORY ACTIVITY

The aim of present study was to assess the anti-inflammatory activity of polyherbal formulation of leaves of Annona squamosa, Azadiracta indica. The mature green leaves of Annona squamosa, Azadiracta indica were collected and authenticated. Extractions of dried leaves and rhizome were carried out with ethanol in soxhlet apparatus. The polyherbal formulation showed the significant anti-inflammatory activity comparable to the standard drug Indomethacin against carrageenan induced rat paw edema method. The polyherbal formulation reduced the inflammation induced by carrageenan by 53.0% and 47.0% on oral administration at 100 mg/kg and 200 mg/kg respectively as compared to the control treated group an analgesic activity comparable to the standard drug tramadol HCl.