DNA-modified carbon paste electrode applied to the study of interaction between Rifampicin (RIF) and DNA in solution and at the electrode surface

被引：29

作者：

Girousi, ST ^{[1
]}

Gherghi, IC ^{[1
]}

Karava, MK ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem, Analyt Chem Lab, Thessaloniki 54124, Greece

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 36卷 / 04期

关键词：

Rifampicin; antibiotic; DNA; electrochemical biosensors; carbon paste electrode;

D O I：

10.1016/j.jpba.2004.08.034

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Rifampicin (RIF) is an antibiotic widely used against tuberculosis and a DNA intercalator. The interaction of RIF with double-stranded (ds) and single-stranded (ss) calf thymus DNA was studied in solution as well as at the electrode surface by means of transfer voltammetry using differential pulse as stripping mode with carbon paste electrode (CPE) at 0.2 M acetate buffer at pH 5.0 and at 0.2 M phosphate buffer pH 7.4. Differentiations in the above-mentioned interaction at different pH values are presented and compared in order to optimize the detection of Rifampicin (RIF). (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：851 / 858

页数：8

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