Neuromodulation of Decision-Making in the Addictive Brain

被引：73
作者：
Fecteau, Shirley [1 ]
Fregni, Felipe [1 ,4 ]
Boggio, Paulo S. [2 ,3 ]
Camprodon, Joan A. [1 ]
Pascual-Leone, Alvaro [1 ]
机构：
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Sch Med,Clin Trials Network, Boston, MA 02215 USA
[2] Univ Prebiteriana Mackenzie, Ctr Hlth & Biol Sci, Cognit Neurosci Lab, Sao Paulo, Brazil
[3] Univ Prebiteriana Mackenzie, Ctr Hlth & Biol Sci, Dev Disorders Program, Sao Paulo, Brazil
[4] Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Clin Trials Network, Boston, MA 02215 USA
来源：
SUBSTANCE USE & MISUSE | 2010年 / 45卷 / 11期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
addiction; craving; decision-making; neurocognition; dorsolateral prefrontal cortex; transcranial magnetic stimulation; transcranial direct current stimulation; TRANSCRANIAL MAGNETIC STIMULATION; DORSOLATERAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; HUMAN MOTOR CORTEX; CIGARETTE AVAILABILITY; ORBITOFRONTAL CORTEX; CORTICAL STIMULATION; EXCITABILITY CHANGES; ENVIRONMENTAL CUES; NEURAL MECHANISMS;
D O I：
10.3109/10826084.2010.482434
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.
引用
收藏
页码：1766 / 1786
页数：21
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