Malignant transformation of oral epithelial dysplasia in Southwest Finland

被引：17

作者：

Nevanpaa, Toni T. ^{[1
]}

Terava, Antti E. ^{[1
]}

Laine, Hanna K. ^{[1
,2
,3
]}

Rautava, Jaana ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Turku, Fac Med, Oral Pathol & Oral Radiol, Turku, Finland

[2] Univ Helsinki, Fac Med, Clinicum, Dept Oral & Maxillofacial Dis, POB 41, Helsinki 00014, Finland

[3] Helsinki Univ Hosp, POB 41, Helsinki 00014, Finland

[4] Univ Helsinki, Fac Med, Dept Pathol, Med, Helsinki, Finland

[5] Helsinki Univ Hosp, HUSLAB, HUS Diagnost Ctr, Helsinki, Finland

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

SQUAMOUS-CELL CARCINOMA; FIELD CANCERIZATION; FOLLOW-UP; CLASSIFICATION; LEUKOPLAKIA; DISORDERS; CANCER;

D O I：

10.1038/s41598-022-12441-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oral epithelial dysplasia (OED) is considered a risk for oral squamous cell carcinoma (OSCC). A meta-analysis estimated a mean malignant transformation rate of 12.1% (95% CI 8.1-17.9). The main target of this study was to define how many OED patients develop OSCC in the hospital district of Southwest Finland. A total of 571 patients diagnosed with OED were identified. Their potential subsequent diagnosis of OSCC was derived from the Finnish Cancer Registry. The risk of OSCC development in OED patients was compared with that of the general population without OED. During a mean follow-up of 5.5 (range 0.1-29.0) years 10.9% of OED patients developed OSCC. OED patients had a 44.7-fold higher risk (95% CI 34.4-56.7) of developing OSCC than the general population. The risk was at its highest within two years of OED diagnosis. OED patients in Southwest Finland have a significantly increased risk of developing OSCC relative to the general population, especially within the first two years of dysplasia diagnosis.

引用

页数：7

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