Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma

被引：48

作者：

Roedl, J. B.

Bleich, S.

Reulbach, U.

von Ahsen, N.

Schloetzer-Schrehardt, U.

Rejdak, R.

Naumann, G. O. H.

Kruse, F. E.

Kornhuber, J.

Juenemann, A. G. M.

机构：

[1] Univ Erlangen Nurnberg, Dept Ophthalmol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Hosp Eye, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany

[4] Univ Erlangen Nurnberg, Dept Med Informat Biometry & Epidemiol, D-91054 Erlangen, Germany

[5] Univ Gottingen, Dept Clin Chem, D-3400 Gottingen, Germany

[6] Univ Eye Hosp, Dept Ophthalmol 1, Lublin, Poland

[7] Polish Acad Sci, Med Res Ctr, Warsaw, Poland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 04期

关键词：

D O I：

10.1007/s00702-006-0556-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined homocysteine (Hcy) levels in aqueous humor (AH) and plasma and their association with B-vitamin levels in patients with primary open-angle glaucoma (POAG) and controls. Both AH Hcy and plasma Hcy levels were significantly increased in POAG, and elevation of AH Hcy and plasma Hcy was a significant risk factor for POAG. In contrast to controls, neither plasma nor AH Hcy of POAG patients demonstrated a significant association with important non-genetic determinants of elevated Hcy such as low B-vitamin levels, increasing age and caffeine consumption. Considering that Hcy is a neurotoxin that induces apoptotic retinal ganglion cell death via stimulation of the N-methyl-D-asparate (NMDA) receptor, increased Hcy concentrations in AH and plasma might contribute to the optic nerve damage in POAG.

引用

页码：445 / 450

页数：6

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