(-)-Epigallocatechin-3-gallate (EGCG) attenuates arsenic-induced cardiotoxicity in rats

被引：38

作者：

Sun, Tao-Li ^{[1
]}

Liu, Zhi ^{[2
,3
,4
]}

Qi, Zheng-Jun ^{[3
]}

Huang, Yong-Pan ^{[2
,5
]}

Gao, Xiao-Qin ^{[4
]}

Zhang, Yon-Yon ^{[2
]}

机构：

[1] Xiangnan Coll, Dept Pharmacol, Chenzhou 423000, Hunan, Peoples R China

[2] Guizhou Med Univ, Dept Pharmacol, Guiyang 550004, Guizhou, Peoples R China

[3] Guizhou Med Univ, Affiliated Hosp 2, Dept Urol Surg & Oncol, Kaili 556000, Guizhou, Peoples R China

[4] Guizhou Med Univ, Dept Histol & Embryol, Guiyang 550004, Guizhou, Peoples R China

[5] Cent S Univ, Dept Pharmacol, Xiangya Rd, Changsha 410078, Hunan, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2016年 / 93卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Arsenic; NaAsO2; (-)-Epigallocatechin-3-gallate (EGCG); Cardiotoxicity; Oxidative stress; INDUCED OXIDATIVE STRESS; GREEN TEA; MYOCARDIAL INJURY; PROTECTIVE ROLE; CALCIUM; ACTIVATION; CATECHINS; PROLONGATION; APOPTOSIS; EXCHANGER;

D O I：

10.1016/j.fct.2016.05.004

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Chronic arsenic exposure in drinking water is associated with the abnormalities of cardiac tissue. Excessive generation of ROS induced by arsenic has a central role in arsenic-induced cardiotoxicity. (-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study was aim to evaluate the effect of EGCG on arsenic-induced cardiotoxicity in vivo and in vitro. Treatment with NaAsO2 seriously affected the morphology and ultrastructure of myocardium, and induced cardiac injuries, oxidative stress, intracellular calcium accumulation and apoptosis in rats. In consistent with in vivo study, the injuries, oxidative stress and apoptosis were also observed in NaAsO2-treated H9c2 cells. All of these effects induced by NaAsO2 were attenuated by EGCG. These results suggest EGCG could attenuate NaAsO2-induced cardiotoxicity, and the mechanism may involve its potent antioxidant capacity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：102 / 110

页数：9

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