PROTECTIVE EFFECTS OF GANODERMA LUCIDUM (CURT.: FR.) P. KARST. ON MAMMARY CELLS OF DMBA INDUCED SPRAGUE DAWLEY RATS

To study the protective effects of carboxy methyl cellulose extracts of Ganoderma lucidum on mammary cells of DMBA induced Sprague dawley rats. Group I noted as control and totally 36 animals were used with six groups. Group II as DMBA induced alone, and Group III was Tamoxifen as positive control respectively while groups VI and V were the treatment groups which were pretreated with 250-500mg/kg bodyweight per day of G.lucidum extract one month before each dose of the DMBA. Group VI as G.lucidum extract alone for checking hypersensitivity. Finally animal serum, liver, kidney was separated and used for calculating the parameters, chemical enzymes. Mammary carcinoma was confirmed by palpation and histopathological examination was studied. Results: Oral administration of CMCGL (250, 500mg/kg body weight) showed beneficial effects on mammary carcinoma. G.lucidum possesses anticancer activity and probably by its antioxidant properties on mammary cells. Significant value was calculated with (p<0.05). These indicate that G.lucidum showed significant tumour reducing activity against DMBA induced mammary carcinoma.