Light-switchable nanoparticles based on amphiphilic diblock, triblock and heterograft polyoxazoline

被引:12
作者
Korchia, L. [1 ]
Bouilhac, C. [1 ]
Aubert, A. [2 ]
Robina, J. -J. [1 ]
Lapinte, V. [1 ]
机构
[1] Univ Montpellier, Equipe Ingn & Architectures Macromol, Inst Charles Gerhardt Montpellier CNRS UM ENSCM U, Montpellier, France
[2] Univ Montpellier, Equipe Mat Avances Catalyse & Sante, Inst Charles Gerhardt Montpellier CNRS UM ENSCM U, Montpellier, France
来源
RSC ADVANCES | 2017年 / 7卷 / 68期
关键词
BLOCK-COPOLYMER MICELLES; PHOTO-CROSS-LINKING; DRUG-DELIVERY; COUMARIN; POLYMERS; CHEMISTRY; PHOTODIMERIZATION; POLYMERIZATION; PHOTOGELATION; NANOCARRIERS;
D O I
10.1039/c7ra07094b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photo-active nanoparticles (NPD, NPT, NPH) were elaborated in water from amphiphilic diblock (D), triblock (T) and heterograft (H) copolymers based on a chromatic unit, coumarin, linked to an alkyl chain and a hydrophilic polyoxazoline chain. Under UV-exposure, for graft copolymers, the coumarin moieties crosslink the nanoparticle core (NPHx) while a simple chain by chain dimerization happens with linear diblock and triblock copolymers (NPDx and NPT). The self-assembly of these copolymers was examined as well as the UV-activity and UV-reversibility of the corresponding NPs by UV spectroscopy. Their stability under light exposure and temperature was also monitored by dynamic light scattering (DLS). Finally, the loading of a lipophilic fluorescent probe (Nile red) into the NP core was evaluated by fluorescence emission. All these data illustrate the tunable size, UV-activity, stability and loading efficiency of the NPs by the starting macromolecular architecture of the amphiphilic copolymers. Triblock copolymers seem to be a promising tool for switchable NPs characterized by two opposite states: NPs alternatively with and without a photo-dimerized core.
引用
收藏
页码:42690 / 42698
页数:9
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