Matteuinterins A-C, three new glycosides from the rhizomes of Matteuccia intermedia

被引：3

作者：

Li, Xue ^{[1
]}

Niu, Li-Ting ^{[1
]}

Meng, Wei-Tong ^{[1
]}

Zhu, Ling-Juan ^{[1
]}

Zhang, Xue ^{[1
]}

Yao, Xin-Sheng ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Sch Tradit Chinese Materia Med, Minist Educ, Shenyang 110016, Liaoning, Peoples R China

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 03期

关键词：

Onocleaceae; Matteuccia intermedia; sesquiterpenoid glycoside; chromone glycoside; phenolic glycoside; inhibitory effect on PGE(2) production; CONSTITUENTS;

D O I：

10.1080/10286020.2019.1681410

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation on the rhizomes of Matteuccia intermedia C.Chr. led to the isolation of three new compounds, named matteuinterins A-C (1-3), together with seven known compounds (4-10). Their structures were elucidated by extensive NMR analyses and chemical derivatization. Compounds 5-10 were evaluated for their anti-inflammatory activities on PGE(2) release in LPS-stimulated RAW 264.7 murine macrophages. Compounds 5 and 10 exhibited inhibitory effect on PGE(2) production in LPS-activated murine macrophages with IC50 values of 17.8 +/- 1.5 and 30.3 +/- 2.1 mu M, respectively.

引用

页码：225 / 232

页数：8

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