Matteuinterins A-C, three new glycosides from the rhizomes of Matteuccia intermedia

被引：3
|
作者：
Li, Xue [1 ]
Niu, Li-Ting [1 ]
Meng, Wei-Tong [1 ]
Zhu, Ling-Juan [1 ]
Zhang, Xue [1 ]
Yao, Xin-Sheng [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Sch Tradit Chinese Materia Med, Minist Educ, Shenyang 110016, Liaoning, Peoples R China
[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 03期
关键词：
Onocleaceae; Matteuccia intermedia; sesquiterpenoid glycoside; chromone glycoside; phenolic glycoside; inhibitory effect on PGE(2) production; CONSTITUENTS;
D O I：
10.1080/10286020.2019.1681410
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical investigation on the rhizomes of Matteuccia intermedia C.Chr. led to the isolation of three new compounds, named matteuinterins A-C (1-3), together with seven known compounds (4-10). Their structures were elucidated by extensive NMR analyses and chemical derivatization. Compounds 5-10 were evaluated for their anti-inflammatory activities on PGE(2) release in LPS-stimulated RAW 264.7 murine macrophages. Compounds 5 and 10 exhibited inhibitory effect on PGE(2) production in LPS-activated murine macrophages with IC50 values of 17.8 +/- 1.5 and 30.3 +/- 2.1 mu M, respectively.
引用
收藏
页码：225 / 232
页数：8
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