Current Issues in Mutagenesis and Carcinogenesis No. 98 - Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer

The existing paradigm governing radiobiology which is fundamental to the estimation of environmental radiation risk, cannot explain the phenomena of radiation induced genomic instability and the bystander effect. Both effects can, however, be understood in terms of the dynamical genome concept, qualitatively described herein. The dynamical genome concept may find further application in better understanding other aspects of biology, most notably the cancer process in general and the consequences of genetic modification. (C) 2000 Elsevier Science B.V. All rights reserved.