Real-time diffuse optical tomography based on structured illumination

被引：88

作者：

Belanger, Samuel ^{[1
,2
]}

Abran, Maxime ^{[1
,2
]}

Intes, Xavier ^{[3
]}

Casanova, Christian ^{[4
]}

Lesage, Frederic ^{[1
,2
]}

机构：

[1] Ecole Polytech, Dept Genie Elect, Montreal, PQ H3C 3A7, Canada

[2] Ecole Polytech, Inst Genie Biomed, Montreal, PQ H3C 3A7, Canada

[3] Rensselaer Polytech Inst, Dept Biomed Engn, Troy, NY 12180 USA

[4] Univ Montreal, Ecole Optometrie, Lab Neurosci Vis, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

digital micromirror devices (DMDs); diffuse optical imaging; real-time imaging; PHOTON MIGRATION; MEDIA;

D O I：

10.1117/1.3290818

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new optical acquisition scheme based on a pair of digital micromirror devices is developed and applied to three-dimensional tomographic imaging of turbid media. By using pairs of illumination-detection patterns with a single detector, we were able to perform high-resolution quantitative volumetric imaging of absorption heterogeneities embedded in optically thick samples. Additionally, a tomographic reconstruction algorithm was implemented on a graphical processor unit to provide optical reconstructions at a frame rate of 2 Hz. The structured illumination method proposed in this work has significant cost advantages over camera systems, as only a single detector is required. This configuration also has the potential to increase frame rate. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3290818]

引用

页数：7

共 22 条

[1] In vivo resolution of multiexponential decays of multiple near-infrared molecular probes by fluorescence lifetime-gated whole-body time-resolved diffuse optical imaging [J].

Akers, Walter ;

Lesage, Frederic ;

Holten, Dewey ;

Achilefu, Samuel .

MOLECULAR IMAGING, 2007, 6 (04) :237-246

[2] Optical tomography in medical imaging [J].

Arridge, SR .

INVERSE PROBLEMS, 1999, 15 (02) :R41-R93

[3] Temporal propagation of spatial information in turbid media [J].

Bassi, Andrea ;

D'Andrea, Cosimo ;

Valentini, Gianluca ;

Cubeddu, Rinaldo ;

Arridge, Simon .

OPTICS LETTERS, 2008, 33 (23) :2836-2838

[4] Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice [J].

Bloch, S ;

Lesage, F ;

McIntosh, L ;

Gandjbakhche, A ;

Liang, KX ;

Achilefu, S .

JOURNAL OF BIOMEDICAL OPTICS, 2005, 10 (05)

[5] Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head [J].

Boas, DA ;

Culver, JP ;

Stott, JJ ;

Dunn, AK .

OPTICS EXPRESS, 2002, 10 (03) :159-170

[6] Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain [J].

Cuccia, DJ ;

Bevilacqua, F ;

Durkin, AJ ;

Tromberg, BJ .

OPTICS LETTERS, 2005, 30 (11) :1354-1356

[7]

CULVER JP, 2006, LIFE SCI SYST APPL W, P1

[8] Diffuse optical imaging of the whole head [J].

Franceschini, Maria Angela ;

Joseph, Danny K. ;

Huppert, Theodore J. ;

Diamond, Solomon G. ;

Boas, David A. .

JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (05)

[9] Time-domain optical mammography SoftScan: Initial results [J].

Intes, X .

ACADEMIC RADIOLOGY, 2005, 12 (08) :934-947

[10] Non-PET functional imaging techniques: optical [J].

Intes, X ;

Chance, B .

RADIOLOGIC CLINICS OF NORTH AMERICA, 2005, 43 (01) :221-+

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