IL-17-producing γδ T cells enhance bone regeneration

被引：286

作者：

Ono, Takehito ^{[1
,2
]}

Okamoto, Kazuo ^{[1
,2
,3
]}

Nakashima, Tomoki ^{[4
,5
,6
]}

Nitta, Takeshi ^{[1
,2
]}

Hori, Shohei ^{[7
]}

Iwakura, Yoichiro ^{[8
]}

Takayanagi, Hiroshi ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy JST, Exploratory Res Adv Technol ERATO Program, Takayanagi Osteonetwork Project, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan

[4] Tokyo Med & Dent Univ, Dept Cell Signaling, Grad Sch Med & Dent Sci, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[5] Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[6] Japan Agcy Med Res & Dev, Core Res Evolut Sci & Technol AMED CREST, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[7] RIKEN Ctr Integrat Med Sci, Lab Immune Homeostasis, Tsurumi Ku, Suehiro Cho 1-7-22, Yokohama, Kanagawa 2300045, Japan

[8] Tokyo Univ Sci, Res Inst Biol Sci, Yamazaki 2669, Noda, Chiba 2780022, Japan

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

关键词：

ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; HOST-DEFENSE; DOUBLE-BLIND; DIFFERENTIATION; IL-17; EXPRESSION; ARTHRITIS; RESPONSES; PROLIFERATION; SECUKINUMAB;

D O I：

10.1038/ncomms10928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that gamma delta T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing gamma delta T cells in skeletal tissue regeneration.

引用

页数：9

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