IL-17-producing γδ T cells enhance bone regeneration

被引：285

作者：

Ono, Takehito ^{[1
,2
]}

Okamoto, Kazuo ^{[1
,2
,3
]}

Nakashima, Tomoki ^{[4
,5
,6
]}

Nitta, Takeshi ^{[1
,2
]}

Hori, Shohei ^{[7
]}

Iwakura, Yoichiro ^{[8
]}

Takayanagi, Hiroshi ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy JST, Exploratory Res Adv Technol ERATO Program, Takayanagi Osteonetwork Project, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan

[4] Tokyo Med & Dent Univ, Dept Cell Signaling, Grad Sch Med & Dent Sci, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[5] Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[6] Japan Agcy Med Res & Dev, Core Res Evolut Sci & Technol AMED CREST, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138549, Japan

[7] RIKEN Ctr Integrat Med Sci, Lab Immune Homeostasis, Tsurumi Ku, Suehiro Cho 1-7-22, Yokohama, Kanagawa 2300045, Japan

[8] Tokyo Univ Sci, Res Inst Biol Sci, Yamazaki 2669, Noda, Chiba 2780022, Japan

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

关键词：

ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; HOST-DEFENSE; DOUBLE-BLIND; DIFFERENTIATION; IL-17; EXPRESSION; ARTHRITIS; RESPONSES; PROLIFERATION; SECUKINUMAB;

D O I：

10.1038/ncomms10928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that gamma delta T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing gamma delta T cells in skeletal tissue regeneration.

引用

页数：9

共 50 条

[1] Characteristics of IL-17-Producing γδ T Cells
O'Brien, Rebecca
Jin, Niyun
Huang, Yafei
Aydintug, M. Kemal
Roark, Christina
Born, Willi
IMMUNITY, 2010, 32 (01) : 1 - 1
[2] Characteristics of IL-17-Producing γδ T Cells Response
Sutton, Caroline E.
Lalor, Stephen J.
Sweeney, Cheryl M.
Brereton, Corinna F.
Lavelle, Ed C.
Mills, Kingston H. G.
IMMUNITY, 2010, 32 (01) : 3 - 4
[3] IL-17-producing T cells in lupus nephritis
Apostolidis, S. A.
Crispin, J. C.
Tsokos, G. C.
LUPUS, 2011, 20 (02) : 120 - 124
[4] How to develop IL-17-producing γδ T cells
Fiala, Gina J.
Silva-Santos, Bruno
IMMUNOLOGY AND CELL BIOLOGY, 2018, 96 (09) : 886 - 887
[5] IL-17-producing γδ T cells and innate lymphoid cells
Sutton, Caroline E.
Mielke, Lisa A.
Mills, Kingston H. G.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (09) : 2221 - 2231
[6] Fate mapping of IL-17-producing T cells in inflammatory responses
Hirota, Keiji
Duarte, Joao H.
Veldhoen, Marc
Hornsby, Eve
Li, Ying
Cua, Daniel J.
Ahlfors, Helena
Wilhelm, Christoph
Tolaini, Mauro
Menzel, Ursula
Garefalaki, Anna
Potocnik, Alexandre J.
Stockinger, Brigitta
NATURE IMMUNOLOGY, 2011, 12 (03) : 255 - U95
[7] IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells
Corpuz, Theresa M.
Vazquez-Lombardi, Rodrigo
Luong, Jason K.
Warren, Joanna
Stolp, Jessica
Christ, Daniel
King, Cecile
Brink, Robert
Sprent, Jonathan
Webster, Kylie E.
JOURNAL OF IMMUNOLOGY, 2017, 199 (07) : 2366 - 2376
[8] IL-17-producing T cells in lung immunity and inflammation
Nembrini, Chiara
Marsland, Benjamin J.
Kopf, Manfred
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (05) : 986 - 994
[9] Diversity of IL-17-producing T lymphocytes
Jiyeon S. Kim
Martha S. Jordan
Cellular and Molecular Life Sciences, 2013, 70 : 2271 - 2290
[10] Diversity of IL-17-producing T lymphocytes
Kim, Jiyeon S.
Jordan, Martha S.
CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (13) : 2271 - 2290

← 1 2 3 4 5 →