Biomarkers of Senescence during Aging as Possible Warnings to Use Preventive Measures

被引：10

作者：

Gasmi, Amin ^{[1
]}

Chirumbolo, Salvatore ^{[2
,3
]}

Peana, Massimiliano ^{[4
]}

Mujawdiya, Pavan Kumar ^{[5
]}

Dadar, Maryam ^{[8
]}

Menzel, Alain ^{[6
]}

Bjorklund, Geir ^{[7
]}

机构：

[1] Soc Francophone Nutritherapie & Nutrigenet Appl, Villeurbanne, France

[2] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[3] CONEM Sci Secretary, Verona, Italy

[4] Univ Sassari, Dept Chem & Pharm, Sassari, Italy

[5] Birla Inst Technol & Sci Pilani, Hyderabad, India

[6] Labs Reunis, Junglinster, Norway

[7] Council Nutr & Environm Med CONEM, Mo I Rana, Norway

[8] Agr Res Educ & Extens Org AREEO, Razi Vaccine & Serum Res Inst, Karaj, Iran

来源：

CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 08期

关键词：

Aging; senescence; biomarkers; inflammation; neurodegeneration; ailments; C-REACTIVE PROTEIN; MEAN CORPUSCULAR VOLUME; CELL DISTRIBUTION WIDTH; GLYCATION END-PRODUCTS; SERUM CREATININE; IMMUNE-SYSTEM; OLDER-ADULTS; NT-PROBNP; CARDIOVASCULAR-DISEASE; LYMPHOCYTE RATIO;

D O I：

10.2174/0929867327999200917150652

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human life expectancy is increasing significantly over time thanks to the improved possibility for people to take care of themselves and the higher availability of food, drugs, hygiene, services, and assistance. The increase in the average age of the population worldwide is, however, becoming a real concern, since aging is associated with the rapid increase in chronic inflammatory pathologies and degenerative diseases, very frequently dependent on senescent phenomena that occur alongside with senescence. Therefore, the search for reliable biomarkers that can diagnose the possible onset or predict the risk of developing a disease associated with aging is a crucial target of current medicine. In this review, we construct a synopsis of the main addressable biomarkers to study the development of aging and the associated ailments.

引用

页码：1471 / 1488

页数：18

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