Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells

被引：24
作者：
Alibert, S
Santelli-Rouvier, C
Castaing, M
Berthlot, M
Spengler, G
Molnar, J
Barbe, J
机构：
[1] Univ Mediterranee, GERCTOP, UMR 6009, CNR,Fac Pharm, F-13385 Marseille 05, France
[2] Univ Nantes, Lab Spectrochim, Fac Sci & Tech, F-44322 Nantes 3, France
[3] Univ Szeged, Inst Microbiol, Szeged, Hungary
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 03期
关键词：
drug efflux; P-glycoprotem; multidrug resistance; cancer cells; 9,10-Dihydro-9,10-ethano and ethenoanthracene derivatives; chemosensitizers; structure activity relationships;
D O I：
10.1016/S0223-5234(03)00018-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A set of 9,10-dihydro-9,10-ethano and ethenoanthracene derivatives was tested with the aim to quantify the effect observed on drug efflux. Structure activity relationships and molecular modeling studies allowed to define topological display of pharmacophoric groups for these reversal agents. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：253 / 263
页数：11
相关论文
共 42 条
[21]   Hydrogen-bond basicity pKHB scale of secondary amines [J].
Graton, J ;
Berthelot, M ;
Laurence, C .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 2001, (11) :2130-2135
[22]   HYDROGEN-BONDING .45. THERMODYNAMIC AND IR STUDY OF THE HYDRATES OF N-METHYLMORPHOLINE OXIDE AND QUINUCLIDINE OXIDE - EFFECT OF HYDRATE STOICHIOMETRY ON STRENGTH OF H-O-H...O-N HYDROGEN-BONDS - IMPLICATIONS FOR THE DISSOLUTION OF CELLULOSE IN AMINE OXIDE SOLVENTS [J].
HARMON, KM ;
AKIN, AC ;
KEEFER, PK ;
SNIDER, BL .
JOURNAL OF MOLECULAR STRUCTURE, 1992, 269 (1-2) :109-121
[23]  
INABA M, 1979, CANCER RES, V39, P2200
[24]   SURFACE GLYCOPROTEIN MODULATING DRUG PERMEABILITY IN CHINESE-HAMSTER OVARY CELL MUTANTS [J].
JULIANO, RL ;
LING, V .
BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 455 (01) :152-162
[25]   LINEAR SOLVATION ENERGY RELATIONSHIPS .23. A COMPREHENSIVE COLLECTION OF THE SOLVATOCHROMIC PARAMETERS, PI-STAR, ALPHA AND BETA, AND SOME METHODS FOR SIMPLIFYING THE GENERALIZED SOLVATOCHROMIC EQUATION [J].
KAMLET, MJ ;
ABBOUD, JLM ;
ABRAHAM, MH ;
TAFT, RW .
JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (17) :2877-2887
[26]   The crystal and molecular structures of 9,10-dihydro-9, 10-ethano- and etheno-anthracenes [J].
Karolak-Wojciechowska, J ;
Trzezwinska, HB ;
Alibert-Franco, S ;
Santelli-Rouvier, C ;
Barbe, J .
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 1998, 28 (12) :905-911
[27]  
KLOPMAN G, 1992, CANCER RES, V52, P4121
[28]   Quantitative structure-activity relationship of multidrug resistance reversal agents [J].
Klopman, G ;
Shi, LM ;
Ramu, A .
MOLECULAR PHARMACOLOGY, 1997, 52 (02) :323-334
[29]   1ST MEASUREMENT OF THE HYDROGEN-BOND BASICITY OF MONOMERIC WATER, PHENOLS, AND WEAKLY BASIC ALCOHOLS [J].
LAURENCE, C ;
BERTHELOT, M ;
HELBERT, M ;
SRAIDI, K .
JOURNAL OF PHYSICAL CHEMISTRY, 1989, 93 (09) :3799-3802
[30]   Observations on the strength of hydrogen bonding [J].
Laurence, C ;
Berthelot, M .
PERSPECTIVES IN DRUG DISCOVERY AND DESIGN, 2000, 18 :39-60
12345