Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells

被引：24
作者：
Alibert, S
Santelli-Rouvier, C
Castaing, M
Berthlot, M
Spengler, G
Molnar, J
Barbe, J
机构：
[1] Univ Mediterranee, GERCTOP, UMR 6009, CNR,Fac Pharm, F-13385 Marseille 05, France
[2] Univ Nantes, Lab Spectrochim, Fac Sci & Tech, F-44322 Nantes 3, France
[3] Univ Szeged, Inst Microbiol, Szeged, Hungary
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 03期
关键词：
drug efflux; P-glycoprotem; multidrug resistance; cancer cells; 9,10-Dihydro-9,10-ethano and ethenoanthracene derivatives; chemosensitizers; structure activity relationships;
D O I：
10.1016/S0223-5234(03)00018-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A set of 9,10-dihydro-9,10-ethano and ethenoanthracene derivatives was tested with the aim to quantify the effect observed on drug efflux. Structure activity relationships and molecular modeling studies allowed to define topological display of pharmacophoric groups for these reversal agents. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：253 / 263
页数：11
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