CTLA-4 Ig as an effective treatment in a patient with type I diabetes mellitus and seropositive rheumatoid arthritis

被引：0
作者：
Fedele, A. L. [1 ]
Alivernini, S. [1 ]
Gremese, E. [1 ]
Ferraccioli, G. [1 ]
机构：
[1] Univ Cattolica Sacro Cuore, Div Rheumatol, I-00168 Rome, Italy
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2016年 / 34卷 / 02期
关键词：
rheumatoid arthritis; type 1 diabetes mellitus; CTLA-4; Ig; ABATACEPT; MODULATION; ASSOCIATION; CELL;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe a patient suffering from seropositive rheumatoid arthritis (RA) and type I diabetes mellitus (T1DM), who achieved a good EULAR response together with an improvement of the glycemic profile under treatment with CTLA-4 Ig. A close association is known to exist between T1DM and RA, and CTLA-4 exon 1 polymorphism has been associated to RA with coexisting autoimmune endocrinopathies. The possible common genetic background and the potential role of CTLA-4 Ig in the early phases of T1DM, could be considered in the therapeutic interventions in RA patients with type 1 diabetes.
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页码：315 / 317
页数：3
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