CTLA-4 Ig as an effective treatment in a patient with type I diabetes mellitus and seropositive rheumatoid arthritis

被引：0
作者：
Fedele, A. L. [1 ]
Alivernini, S. [1 ]
Gremese, E. [1 ]
Ferraccioli, G. [1 ]
机构：
[1] Univ Cattolica Sacro Cuore, Div Rheumatol, I-00168 Rome, Italy
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2016年 / 34卷 / 02期
关键词：
rheumatoid arthritis; type 1 diabetes mellitus; CTLA-4; Ig; ABATACEPT; MODULATION; ASSOCIATION; CELL;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe a patient suffering from seropositive rheumatoid arthritis (RA) and type I diabetes mellitus (T1DM), who achieved a good EULAR response together with an improvement of the glycemic profile under treatment with CTLA-4 Ig. A close association is known to exist between T1DM and RA, and CTLA-4 exon 1 polymorphism has been associated to RA with coexisting autoimmune endocrinopathies. The possible common genetic background and the potential role of CTLA-4 Ig in the early phases of T1DM, could be considered in the therapeutic interventions in RA patients with type 1 diabetes.
引用
收藏
页码：315 / 317
页数：3
相关论文
共 16 条
  • [1] CTLA41g: Bridging the basic immunology with clinical application
    Bluestone, JA
    St Clair, EW
    Turka, LA
    [J]. IMMUNITY, 2006, 24 (03) : 233 - 238
  • [2] Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis
    Cutolo, Maurizio
    Nadler, Steven G.
    [J]. AUTOIMMUNITY REVIEWS, 2013, 12 (07) : 758 - 767
  • [3] Abatacept (cytotoxic T lymphocyte antigen 4-immunoglobulin) improves B cell function and regulatory T cell inhibitory capacity in rheumatoid arthritis patients non-responding to anti-tumour necrosis factor-α agents
    Diamanti, A. Picchianti
    Rosado, M. M.
    Scarsella, M.
    Germano, V.
    Giorda, E.
    Cascioli, S.
    Lagana, B.
    D'Amelio, R.
    Carsetti, R.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 177 (03) : 630 - 640
  • [4] Abatacept: A Review of its Use in the Management of Rheumatoid Arthritis
    Keating, Gillian M.
    [J]. DRUGS, 2013, 73 (10) : 1095 - 1119
  • [5] Specific Association of Type 1 Diabetes Mellitus With Anti-Cyclic Citrullinated Peptide-Positive Rheumatoid Arthritis
    Liao, Katherine P.
    Gunnarsson, Marie
    Kallberg, Henrik
    Ding, Bo
    Plenge, Robert M.
    Padyukov, Leonid
    Karlson, Elizabeth W.
    Klareskog, Lars
    Askling, Johan
    Alfredsson, Lars
    [J]. ARTHRITIS AND RHEUMATISM, 2009, 60 (03): : 653 - 660
  • [6] The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: a Danish nationwide cohort study
    Lindhardsen, Jesper
    Ahlehoff, Ole
    Gislason, Gunnar Hilmar
    Madsen, Ole Rintek
    Olesen, Jonas Bjerring
    Torp-Pedersen, Christian
    Hansen, Peter Riis
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (06) : 929 - 934
  • [7] Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment
    Orban, Tihamer
    Bundy, Brian
    Becker, Dorothy J.
    DiMeglio, Linda A.
    Gitelman, Stephen E.
    Goland, Robin
    Gottlieb, Peter A.
    Greenbaum, Carla J.
    Marks, Jennifer B.
    Monzavi, Roshanak
    Moran, Antoinette
    Peakman, Mark
    Raskin, Philip
    Russell, William E.
    Schatz, Desmond
    Wherrett, Diane K.
    Wilson, Darrell M.
    Krischer, Jeffrey P.
    Skyler, Jay S.
    [J]. DIABETES CARE, 2014, 37 (04) : 1069 - 1075
  • [8] Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
    Orban, Tihamer
    Bundy, Brian
    Becker, Dorothy J.
    DiMeglio, Linda A.
    Gitelman, Stephen E.
    Goland, Robin
    Gottlieb, Peter A.
    Greenbaum, Carla J.
    Marks, Jennifer B.
    Monzavi, Roshanak
    Moran, Antoinette
    Raskin, Philip
    Rodriguez, Henry
    Russell, William E.
    Schatz, Desmond
    Wherrett, Diane
    Wilson, Darrell M.
    Krischer, Jeffrey P.
    Skyler, Jay S.
    [J]. LANCET, 2011, 378 (9789) : 412 - 419
  • [9] Comorbidities are associated with poorer outcomes in community patients with rheumatoid arthritis
    Ranganath, Veena K.
    Maranian, Paul
    Elashoff, David A.
    Woodworth, Thasia
    Khanna, Dinesh
    Hahn, Theodore
    Sarkisian, Catherine
    Kremer, Joel M.
    Furst, Daniel E.
    Paulus, Harold E.
    [J]. RHEUMATOLOGY, 2013, 52 (10) : 1809 - 1817
  • [10] Scarsi M, 2014, CLIN EXP RHEUMATOL, V32, P204
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