Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

被引：24

作者：

Li, Ningbo ^{[1
,3
]}

Wang, Yijun ^{[1
]}

Liu, Feijun ^{[1
]}

Zhao, Xin ^{[1
]}

Xu, Xinhua ^{[2
]}

An, Quan ^{[3
]}

Yun, Keming ^{[4
]}

机构：

[1] Shanxi Med Univ, Basic Med Coll, Taiyuan 030001, Shanxi, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

[3] China Inst Radiat Protect, Taiyuan 030006, Shanxi, Peoples R China

[4] Shanxi Med Univ, Sch Forens Med, Jinzhong 030619, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2020年 / 34卷 / 03期

基金：

山西省青年科学基金; 中国国家自然科学基金;

关键词：

Dihydropyrimidones; thiones; Perfluorooctanesulfonate; zirconium (IV)-salophen; Biginelli synthesis; Solvent-free; ONE-POT SYNTHESIS; STRONG LEWIS-ACIDS; BIGINELLI REACTION; CONDENSATION REACTION; RECYCLABLE CATALYST; DIHYDROPYRIMIDINONES; CHLORIDE; 3-COMPONENT; COMPLEXES; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES;

D O I：

10.1002/aoc.5454

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl-2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniques (NMR, IR, HRMS, TG-DSC, conductivity and acidity measurements), and was found to be air-stable, water tolerant, thermally stable and strongly Lewis-acidic. Complex 1 exhibited high catalytic efficiency for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones via the Biginelli reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent-free conditions. Furthermore, complex 1 could be reused 5 times with minimal changes in catalytic efficiency. Compared with previously reported methods, the important features of this protocol are the solvent-free conditions, the short reaction times, the wide substrate compatibility, the high efficiency and the good reusability.

引用

页数：10

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