Antimicrobial susceptibility of bacteremic vancomycin-resistant Enterococcus faecium to eravacycline, omadacycline, lipoglycopeptides, and other comparator antibiotics: Results from the 2019-2020 Nationwide Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

被引：12

作者：

Tsai, Hsih-Yeh ^{[1
]}

Lee, Yu-Lin ^{[2
,3
]}

Liu, Po-Yu ^{[4
]}

Lu, Min-Chi ^{[5
]}

Shao, Pei-Lan ^{[6
]}

Lu, Po-Liang ^{[7
]}

Cheng, Shu-Hsing ^{[8
,9
]}

Ko, Wen-Chien ^{[10
]}

Lin, Chi-Ying ^{[11
]}

Wu, Ting-Shu ^{[12
]}

Yen, Muh-Yong ^{[13
,14
]}

Wang, Lih-Shinn ^{[15
,16
]}

Liu, Chang-Pan ^{[17
,18
]}

Lee, Wen-Sen ^{[19
,20
]}

Shi, Zhi-Yuan ^{[21
]}

Chen, Yao-Shen ^{[22
,23
]}

Wang, Fu-Der ^{[23
]}

Tseng, Shu-Hui ^{[24
,25
]}

Chen, Yu-Hui ^{[26
]}

Sheng, Wang-Huei ^{[27
]}

Lee, Chun-Ming ^{[28
,29
]}

Chen, Yen-Hsu ^{[7
]}

Liao, Chun-Hsing ^{[1
]}

Hsueh, Po-Ren ^{[27
,30
]}

机构：

[1] Far Eastern Mem Hosp, Dept Internal Med, New Taipei, Taiwan

[2] Changhua Christian Hosp, Dept Internal Med, Changhua, Taiwan

[3] Natl Chung Hsing Univ, Inst Genom & Bioinformat, Taichung, Taiwan

[4] Taichung Vet Gen Hosp, Dept Internal Med, Div Infect Dis, Taichung, Taiwan

[5] China Med Univ, Sch Med, Dept Microbiol & Immunol, Taichung, Taiwan

[6] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Pediat, Hsinchu, Taiwan

[7] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Internal Med, Kaohsiung, Taiwan

[8] Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Internal Med, Taoyuan, Taiwan

[9] Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth, Taipei, Taiwan

[10] Natl Cheng Kung Univ, Med Coll & Hosp, Dept Internal Med, Tainan, Taiwan

[11] Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Internal Med, Yunlin, Taiwan

[12] Chang Gung Univ, Chang Gung Mem Hosp Linkou, Coll Med, Div Infect Dis,Dept Internal Med, Taoyuan, Taiwan

[13] Taipei City Hosp, Div Infect Dis, Taipei, Taiwan

[14] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

[15] Buddhist Tzu Chi Gen Hosp, Dept Internal Med, Div Infect Dis, Hualien, Taiwan

[16] Tzu Chi Univ, Hualien, Taiwan

[17] MacKay Mem Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[18] MacKay Med Coll, New Taipei, Taiwan

[19] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[20] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei, Taiwan

[21] Taichung Vet Gen Hosp, Dept Internal Med, Taichung, Taiwan

[22] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

[23] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

[24] Taipei Vet Gen Hosp, Dept Med, Div Infect Dis, Taipei, Taiwan

[25] Ctr Dis Control & Prevent, Minist Hlth & Welf, Taipei, Taiwan

[26] Chi Mei Hosp, Infect Control Ctr, Liouying, Taiwan

[27] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Div Infect Dis,Dept Internal Med, Taipei, Taiwan

[28] St Josephs Hosp, Dept Internal Med, Huwei Township, Yunlin, Taiwan

[29] MacKay Jr Coll Med Nursing & Management, Taipei, Taiwan

[30] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Lab Med, Taipei, Taiwan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2021年 / 58卷 / 01期

关键词：

Vancomycin-resistant Enterococcus faecium; Eravacycline; Tedizolid; Omadacycline; Lipoglycopeptides; DAPTOMYCIN; EPIDEMIOLOGY; TIGECYCLINE; MECHANISMS;

D O I：

10.1016/j.ijantimicag.2021.106353

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Multicenter surveillance of antimicrobial susceptibility was performed for 235 vancomycin-resistant En-terococcus faecium (VREfm) isolates from 18 Taiwanese hospitals. The minimum inhibitory concentrations (MICs) of eravacycline, omadacycline, lipoglycopeptides, and other comparator antibiotics were deter-mined using the broth microdilution method. Nearly all isolates of VREfm were not susceptible to te-icoplanin, dalbavancin, and telavancin, with susceptibility rates of 0.5%, 1.7% and 0.5%, respectively. Tige-cycline and eravacycline were active against 93.2% and 89.7% of the VREfm isolates, respectively. More -over, the susceptibility rates of quinupristin/dalfopristin, tedizolid, and linezolid were 59.1%, 84.2%, and 77.4%, respectively. Additionally, 94% of the VREfm isolates were classified as susceptible to daptomycin, and the MICs of omadacycline required to inhibit VREfm growth by 50% and 90% were 0.12 and 0.5 mg/L, respectively. Susceptibility rates of VREfm isolates to synthetic tetracyclines and daptomycin were slightly lower and to oxazolidinone-class antibiotics were much lower in Taiwan than those in other parts of the world. Continuous monitoring of VREfm resistance to novel antibiotics, including synthetic tetracyclines, oxazolidinone-class antibiotics, and daptomycin, is needed in Taiwan. (c) 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.

引用

页数：5

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