PIM1/STAT3 axis: a potential co-targeted therapeutic approach in triple-negative breast cancer

被引：14
作者：
Mahata, Sutapa [1 ]
Sahoo, Pranab K. [1 ]
Pal, Ranita [1 ]
Sarkar, Sinjini [1 ]
Mistry, Tanuma [1 ]
Ghosh, Sushmita [1 ]
Nasare, Vilas D. [1 ]
机构：
[1] Chittaranjan Natl Canc Inst, Dept Pathol & Canc Screening, 37 SP Mukherjee Rd, Kolkata 700026, India
来源：
MEDICAL ONCOLOGY | 2022年 / 39卷 / 05期
关键词：
PIM1; STAT3; Triple-negative breast cancer; PIM inhibitors; inhibitors; PIM KINASE INHIBITOR; SMALL-MOLECULE INHIBITOR; STAT3 SIGNALING PATHWAY; EPIDERMAL-GROWTH-FACTOR; CELL LUNG-CANCER; PROTOONCOGENE PIM-1; DOWN-REGULATION; TRANSCRIPTION; PANCREATIC-CANCER; TUMOR PROGRESSION;
D O I：
10.1007/s12032-022-01675-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Triple-negative breast cancer lacks an expression of ER, PR, and Her-2, has a poor prognosis, and there are no target therapies available. Therapeutic options to treat TNBC are limited and urgently needed. Strong evidence indicates that molecular signaling pathways have a significant function to regulate biological mechanisms and their abnormal expression endows with the development of cancer. PIM kinase is overexpressed in various human cancers including TNBC which is regulated by various signaling pathways that are crucial for cancer cell proliferation and survival and also make PIM kinase as an attractive drug target. One of the targets of the STAT3 signaling pathway is PIM1 that plays a key role in tumor progression and transformation. In this review, we accumulate the current scenario of the PIM-STAT3 axis that provides insights into the PIM1 and STAT3 inhibitors which can be developed as potential co-inhibitors as prospective anticancer agents.
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页数：11
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