MicroRNA-146a contributes to CD4+ T lymphocyte differentiation in patients with thyroid ophthalmopathy

被引:1
|
作者
Yang, Wen-Juan [1 ]
Ma, Peng-Fei [2 ]
Li, Shu-Ping [3 ]
Su, Hong [4 ]
Liu, Yun-Jia [3 ]
机构
[1] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Ophthalmol, 24 Jinghua Rd, Luoyang 471003, Henan, Peoples R China
[2] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Gen Surg, Luoyang 471003, Henan, Peoples R China
[3] Shenzhou Eye Hosp, Dept Ophthalmol, Luoyang 471000, Henan, Peoples R China
[4] 150th Cent Hosp PLA, Dept Ophthalmol, Luoyang 471031, Henan, Peoples R China
来源
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2017年 / 9卷 / 04期
关键词
MiR-146a; CD4(+) T lymphocyte; differentiation; thyroid ophthalmopathy; GRAVES OPHTHALMOPATHY; AUTOIMMUNE-DISEASES; IMMUNE-RESPONSES; CELL RESPONSES; EXPRESSION; MIR-146A; PATHOGENESIS; TH1; INFLAMMATION; PROLIFERATION;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MicroRNA-146a (miR-146a) is associated with human inflammatory disease, such as thyroid-associated ophthalmopathy (TAO), but its role in human T cells and relevance to TAO remains ambiguous. In this study, T cells of TAO patients showed downregulated expression of miR-146a. We characterized miR-146a in T cells and examined miR-146a as a critical inhibitor of Th1 differentiation processes. MiR-146a inhibited Th1 differentiation processes and cell proliferation of T-lymphocytes. Thus, the results showed that miR-146a was a potent inhibitor of Th1 differentiation and cell proliferation of human T cells and dysregulation of miR-146a contributed to the pathogenesis of TAO.
引用
收藏
页码:1801 / 1809
页数:9
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