Quantitative chirality sensing of amines and amino alcohols via Schiff base formation with a stereodynamic UV/CD probe

被引：34

作者：

De los Santos, Zeus A. ^{[1
]}

Ding, Ransheng ^{[1
]}

Wolf, Christian ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 06期

基金：

美国国家科学基金会;

关键词：

CIRCULAR-DICHROISM SPECTROSCOPY; ENANTIOMERIC EXCESS; RAPID-DETERMINATION; SIMULTANEOUSLY DETERMINE; FLUORESCENT SENSOR; CARBOXYLIC-ACIDS; SUBSTRATE; COMPLEXES; IDENTITY; CHEMOSENSOR;

D O I：

10.1039/c5ob02529j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereodynamic chemosensor that can be used for simultaneous determination of the absolute configuration, enantiomeric composition and total concentration of chiral amines and amino alcohols based on two fast optical measurements was prepared and tested. The free sensor is CD-silent and produces characteristic blue-shifted UV and CD signals upon substrate binding via Schiff base formation. The potential in high-throughput screening applications and for rational sensor developments are discussed.

引用

页码：1934 / 1939

页数：6

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