A new antiplatelet diarylheptanoid from Alpinia blepharocalyx

被引：73

作者：

Dong, H

Chen, SX

Xu, HX

Kadota, S

Namba, T

机构：

[1] Natl Univ Singapore, Biosci Ctr, Singapore 119260, Singapore

[2] Dalhousie Univ, Dept Chem, Halifax, NS B3H 3J5, Canada

[3] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Toyama 93001, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期

关键词：

D O I：

10.1021/np970293i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-(1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Structures of these compounds were elucidated by spectroscopic and chemical means.

引用

页码：142 / 144

页数：3

共 15 条

[1] ELECTRONIC AGGREGOMETER - NOVEL DEVICE FOR ASSESSING PLATELET BEHAVIOR IN BLOOD [J].

CARDINAL, DC ;

FLOWER, RJ .

JOURNAL OF PHARMACOLOGICAL METHODS, 1980, 3 (02) :135-158

[2] QUANTITATION OF PLATELET MASS DURING AGGREGATION IN THE ELECTRONIC (WELLCOME) WHOLE-BLOOD AGGREGOMETER [J].

CHALLEN, A ;

BRANCH, WJ ;

CUMMINGS, JH .

JOURNAL OF PHARMACOLOGICAL METHODS, 1982, 8 (02) :115-122

[3]

INGERMANWOJENSK.C, 1984, J THROMB HAEMOSTAS, V2, P154

[4] PHENOLIC-COMPOUNDS FROM THE RHIZOMES OF ALPINIA-SPECIOSA [J].

ITOKAWA, H ;

MORITA, M ;

MIHASHI, S .

PHYTOCHEMISTRY, 1981, 20 (11) :2503-2506

[5]

KADOTA S, 1994, CHEM PHARM BULL, V42, P2647, DOI 10.1248/cpb.42.2647

[6] Blepharocalyxins A and B, novel diarylheptanoids from Alpinia blepharocalyx, and their inhibitory effect on NO formation in murine macrophages [J].

Kadota, S ;

Prasain, JK ;

Li, JX ;

Basnet, P ;

Dong, H ;

Tani, T ;

Namba, T .

TETRAHEDRON LETTERS, 1996, 37 (40) :7283-7286

[7]

KUROYANAGI M, 1983, CHEM PHARM BULL, V31, P1544

[8]

KUROYANAGI M, 1970, YAKUGAKU ZASSHI, V11, P1467

[9] Novel antiplatelet constituents from Formosan Moraceous plants [J].

Lin, CN ;

Lu, CM ;

Lin, HC ;

Fang, SC ;

Shieh, BJ ;

Hsu, MF ;

Wang, JP ;

Ko, FN ;

Teng, CM .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (09) :834-838

[10] A NEW FLAVANONE FROM ACHYROCLINE-FLACCIDA [J].

NORBEDO, C ;

FERRARO, G ;

COUSSIO, JD .

JOURNAL OF NATURAL PRODUCTS, 1982, 45 (05) :635-636

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