Synthesis, anti-HIV and anti-oxidant activities of caffeoyl 5,6-anhydroquinic acid derivatives

被引：19

作者：

Ma, Chao-Mei ^{[1
]}

Kawahata, Takuya ^{[2
]}

Hattori, Masao ^{[1
]}

Otake, Toru ^{[2
]}

Wang, Lili ^{[3
]}

Daneshtalab, Mohsen ^{[3
]}

机构：

[1] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Osaka Prefectural Inst Publ Hlth, Osaka 5370025, Japan

[3] Mem Univ Newfoundland, Sch Pharm, St John, NF A1B 3V6, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 02期

关键词：

Caffeoyl 5,6-anhydroquinic acid; 5,6-Anhydroquinic acid; Chlorogenic acid; Anti-oxidant; Anti-HIV; CHLOROGENIC ACID; INHIBITORS;

D O I：

10.1016/j.bmc.2009.11.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In our continued research on chlorogenic acid analogues and derivatives with improved bioactivity, we have synthesized some caffeoyl 5,6-anhydroquinic acid derivatives. The 1,7 acetonides of chlorogenic acid ( 15), and of the mono-caffeoyl 5,6-anhydroquinic acids (7-8) showed appreciable anti-HIV activity. The 3,4-dicaffeoyl 5,6-anhydroquinic acid ( 12) exhibited an anti-HIV activity twice as that of 3,5-dicaffeoylquinic acid ( 22). The caffeoyl 5,6-anhydroquinic acid derivatives displayed potent anti-oxidant activities. The mono-caffeoyl 5,6-anhydroquinic acids (10-11) were more than twice stronger than chlorogenic acid ( 21) on SOD-like activity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：863 / 869

页数：7

共 11 条

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