Fast inactivation in potassium channels: An interplay of cytoplasmic domains

被引：0
|
作者：
Sankaranarayanan, Kavitha [1 ]
Usman, Hyder [1 ]
Mathew, M. K. [1 ]
机构：
[1] TIFR, NCBS, Bangalore 560065, Karnataka, India
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 388卷 / 03期
关键词：
Voltage-gated potassium channel; hKv1.4; Inactivation; Ball and chain; Tetramerization domain; Chimera; N-TYPE INACTIVATION; GATED K+ CHANNEL; T1; DOMAIN; FUNCTIONAL-ROLE; NMR STRUCTURE; BETA-SUBUNIT; TERMINUS; ACTIVATION; MECHANISMS; RECEPTOR;
D O I：
10.1016/j.bbrc.2009.08.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fast inactivation in voltage-gated potassium channels has traditionally been associated exclusively with the N-terminus. Here, we explore the role of the T1 domain using a series of chimeric channels. A chimeric channel, 4N/2, (N-terminus from the rapidly inactivating hKv1.4, and the channel body from the non-inactivating hKv1.2), exhibited slower and incomplete inactivation as compared to the wild-type hKv1.4. Replacing the T1 domain of 4N2 with that from hKv1.2 (4N/2T1/2), restored inactivation, while that from hKv1.1 (4N/1T1/2) completely abolished inactivation. Based on these observations, we hypothesize a correlation between the tetramerization domain and the putative inactivation domain receptor in the process of rapid inactivation of hKv1 channels. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：490 / 495
页数：6
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