Fast inactivation in potassium channels: An interplay of cytoplasmic domains

被引：0

作者：

Sankaranarayanan, Kavitha ^{[1
]}

Usman, Hyder ^{[1
]}

Mathew, M. K. ^{[1
]}

机构：

[1] TIFR, NCBS, Bangalore 560065, Karnataka, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 388卷 / 03期

关键词：

Voltage-gated potassium channel; hKv1.4; Inactivation; Ball and chain; Tetramerization domain; Chimera; N-TYPE INACTIVATION; GATED K+ CHANNEL; T1; DOMAIN; FUNCTIONAL-ROLE; NMR STRUCTURE; BETA-SUBUNIT; TERMINUS; ACTIVATION; MECHANISMS; RECEPTOR;

D O I：

10.1016/j.bbrc.2009.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fast inactivation in voltage-gated potassium channels has traditionally been associated exclusively with the N-terminus. Here, we explore the role of the T1 domain using a series of chimeric channels. A chimeric channel, 4N/2, (N-terminus from the rapidly inactivating hKv1.4, and the channel body from the non-inactivating hKv1.2), exhibited slower and incomplete inactivation as compared to the wild-type hKv1.4. Replacing the T1 domain of 4N2 with that from hKv1.2 (4N/2T1/2), restored inactivation, while that from hKv1.1 (4N/1T1/2) completely abolished inactivation. Based on these observations, we hypothesize a correlation between the tetramerization domain and the putative inactivation domain receptor in the process of rapid inactivation of hKv1 channels. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：490 / 495

页数：6

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