Site-Selective Peptide/Protein Cleavage

被引：17
作者：
Ni, Jizhi [1 ,2 ]
Kanai, Motomu [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
[2] JST ERATO, Kanai Life Sci Catalysis Project, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
来源：
SITE-SELECTIVE CATALYSIS | 2016年 / 372卷
关键词：
Cleavage; Degradation; Peptide bonds; Proteins; Site-selectivity; ISLET AMYLOID POLYPEPTIDE; TRANSITION-METAL-COMPLEXES; TETRANUCLEAR ZINC CLUSTER; NEUTRAL AQUEOUS-SOLUTION; PEPTIDE-BOND HYDROLYSIS; NONHEME IRON ENZYMES; COLI RNA-POLYMERASE; PALLADIUM(II) COMPLEXES; PROTEIN CLEAVAGE; HISTONE H2A;
D O I：
10.1007/128_2015_652
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Site-selective peptide/protein degradation through chemical cleavage methods is an important modification of biologically relevant macromolecules which complements enzymatic hydrolysis. In this review, recent progress in chemical, site-selective peptide bond cleavage is overviewed, with an emphasis on postulated mechanisms and their implications on reactivity, selectivity, and substrate scope.
引用
收藏
页码：103 / 123
页数：21
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