Site-Selective Peptide/Protein Cleavage

被引：17

作者：

Ni, Jizhi ^{[1
,2
]}

Kanai, Motomu ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] JST ERATO, Kanai Life Sci Catalysis Project, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

来源：

SITE-SELECTIVE CATALYSIS | 2016年 / 372卷

关键词：

Cleavage; Degradation; Peptide bonds; Proteins; Site-selectivity; ISLET AMYLOID POLYPEPTIDE; TRANSITION-METAL-COMPLEXES; TETRANUCLEAR ZINC CLUSTER; NEUTRAL AQUEOUS-SOLUTION; PEPTIDE-BOND HYDROLYSIS; NONHEME IRON ENZYMES; COLI RNA-POLYMERASE; PALLADIUM(II) COMPLEXES; PROTEIN CLEAVAGE; HISTONE H2A;

D O I：

10.1007/128_2015_652

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Site-selective peptide/protein degradation through chemical cleavage methods is an important modification of biologically relevant macromolecules which complements enzymatic hydrolysis. In this review, recent progress in chemical, site-selective peptide bond cleavage is overviewed, with an emphasis on postulated mechanisms and their implications on reactivity, selectivity, and substrate scope.

引用

收藏

页码：103 / 123

页数：21

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