A novel synthetic route to 2-amino and 2-alkylamino-1,3,5-triazines based on nucleophilic aromatic substitution of hydrogen: The first reactions of 1,3,5-triazine with nucleophiles without ring decomposition

被引：18

作者：

Gulevskaya, Anna V. ^{[1
]}

Maes, Bert U. W. ^{[1
]}

Meyers, Caroline ^{[1
]}

机构：

[1] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium

来源：

SYNLETT | 2007年 / 01期

关键词：

nucleophilic aromatic substitution of hydrogen; 1,3,5-triazine; oxidative (alkyl)amination; 2-amino-1,3,5-triazine; 2-alkylamino-1,3,5-triazines; rotational isomerism;

D O I：

10.1055/s-2006-958448

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Amino- and 2-alkylamino-1,3,5-triazines were smoothly obtained by oxidative (alkyl)amination of 1,3,5-triazine in ammonia-ethanol or alkylamine-ethanol with bis(pyridine)silver(I)permanganate (AgPy2MnO4) as the oxidant. These transformations are the first reactions of 1,3,5-triazine with nucleophiles without ring decomposition and the first examples of nucleophilic substitution of hydrogen on this substrate.

引用

页码：71 / 74

页数：4

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