Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

被引：54

作者：

Li, Yuying ^{[1
]}

Wang, Kan ^{[2
]}

Zhou, Kaixiang ^{[1
]}

Guo, Wentao ^{[1
]}

Dai, Bin ^{[2
]}

Liang, Yi ^{[2
]}

Dai, Jiapei ^{[3
]}

Cui, Mengchao ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

[2] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China

[3] South Cent Univ Nationalities, Wuhan Inst Neurosci & Neuroengn, Wuhan 430074, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 63期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO DETECTION; INTRAMOLECULAR CHARGE-TRANSFER; CASCADE HYPOTHESIS; PLAQUES; PATHOLOGY; THERAPEUTICS; FLUOROPHORES; FLUORESCENCE;

D O I：

10.1039/c8cc05259j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel D-pi-A-pi-D probes were investigated for the detection of A beta plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and A beta aggregates (K-d = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label A beta plaques in vivo.

引用

页码：8717 / 8720

页数：4

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